Chemical Name: 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Biological ActivityCDPPB is a brain penetrant, selective positive allosteric modulator at the mGlu5 receptor (EC50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Chen et al.
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
Lindsley et al.
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rats behavioral models.
Kinney et al.
Citations for CDPPB
The citations listed below are publications that use Tocris products. Selected citations for CDPPB include:
5 Citations: Showing 1 - 5
A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mice models of Alzheimer's disease.
Authors: Bellozi Et al.
Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.
Authors: Vicidomini Et al.
Mol Psychiatry 2017;22:689
OE Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5.
Authors: Martinez Et al.
Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.
Authors: Arsenault Et al.
PLoS One 2015;10:e0142093
Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
Authors: Pacey Et al.
Front Pharmacol 2011;338:897
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