Catalog Number: 3235
Chemical Name: 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Biological Activity
Brain penetrant, selective positive allosteric modulator at the mGlu5 receptor (EC50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.
Technical Data
  • M.Wt:
    364.4
  • Formula:
    C23H16N4O
  • Solubility:
    Soluble to 75 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    781652-57-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)
Background References
  1. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
    Lindsley et al.
    J.Med.Chem., 2004;47:5825
  2. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rats behavioral models.
    Kinney et al.
    J.Pharmacol.Exp.Ther., 2005;313:199
  3. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
    Chen et al.
    Mol.Pharmacol., 2007;71:1389
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CDPPB include:

2 Citations: Showing 1 - 2
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  1. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.
    Authors: Arsenault Et al.
    PLoS One 2015;10:e0142093
  2. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
    Authors: Pacey Et al.
    Front Pharmacol 2011;338:897

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