CDPPB

  ( 4 citations )    
Product Datasheet
Catalog Number:3235
Chemical Name:3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Brain penetrant, selective positive allosteric modulator at the mGlu5 receptor (EC50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.
Technical Data
  • M.Wt:
    364.4
  • Formula:
    C23H16N4O
  • Solubility:
    Soluble to 75 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    781652-57-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CDPPB include:

4 Citations: Showing 1 - 4
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  1. Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5.
    Authors: Martinez Et al.
    Eneuro  2016;3
  2. Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.
    Authors: Vicidomini Et al.
    Mol Psychiatry  2016;
  3. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.
    Authors: Arsenault Et al.
    PLoS One  2015;10:e0142093
  4. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
    Authors: Pacey Et al.
    Front Pharmacol  2011;338:897

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