Cesium chloride

Biological Activity

Potassium channel blocker; inhibits the pacemaker current (I_f) and the hyperpolarization-activated cationic current (I_h). Prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

1. Cesium chloride protects cerebellar granule neurons from apoptosis induced by low potassium.
   Zhong et al.
   Int.J.Dev.Neurosci., 2007;25:359
2. Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits.
   Sharma et al.
   Neurol.Res., 2012;34:291
3. Effects of ionic channel antagonists barium, cesium, and UL-FS-49 on vagal slowing of atrial rate in dogs.
   Wallick et al.
   Am.J.Physiol., 1997;273:H2155

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