Cesium chloride
Biological Activity
Potassium channel blocker; inhibits the pacemaker current (If) and the hyperpolarization-activated cationic current (Ih). Prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cesium chloride protects cerebellar granule neurons from apoptosis induced by low potassium.
Zhong et al.
Int.J.Dev.Neurosci., 2007;25:359 -
Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits.
Sharma et al.
Neurol.Res., 2012;34:291 -
Effects of ionic channel antagonists barium, cesium, and UL-FS-49 on vagal slowing of atrial rate in dogs.
Wallick et al.
Am.J.Physiol., 1997;273:H2155
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CsCl was used to study cancerous neurons to understand their mechanism of change of pH. The product worked ideally on lab conditions and the paper was eventually published. Great affordable buy.
