CGS 15943

Catalog # Availability Size / Price Qty
CGS 15943 | CAS No. 104615-18-1 | Non-selective Adenosine Receptor Antagonists
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Description: Potent adenosine receptor antagonist

Chemical Name: 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Purity: ≥99%

Product Details
Citations (7)
Supplemental Products

Biological Activity

CGS 15943 is a potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively). Inhibits the catalytic subunit of the class IB PI3K isoform p110γ (IC50 = 1.1 μM). Blocks HCC and HDAC cell proliferation in vitro via inhibition of the PI3K/Akt pathway; reduces proliferation of ER+ breast cancer cells. Also acts as a BMP-4 mimetic to stimulate osteogenic differentiation. Orally active in vivo.

Technical Data

Soluble to 5 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist.
    Ghai et al.
    J.Pharmacol.Exp.Ther., 1987;242:784
  2. Adenosine receptors and their ligands.
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  3. Biochemical characterization of the triazoloquinazoline CGS 15943, a novel, non-xanthine adenosine antagonist.
    Williams et al.
    J.Pharmacol.Exp.Ther., 1987;241:415

Product Datasheets

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Citations for CGS 15943

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7 Citations: Showing 1 - 7


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