Catalog Number: 1699
Chemical Name: 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Biological Activity
Potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively). Orally active in vivo.
Technical Data
  • M.Wt:
    285.69
  • Formula:
    C13H8ClN5O
  • Solubility:
    Soluble to 5 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    104615-18-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Adenosine receptors and their ligands.
    Klot
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  2. Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist.
    Ghai et al.
    J.Pharmacol.Exp.Ther., 1987;242:784
  3. Biochemical characterization of the triazoloquinazoline CGS 15943, a novel, non-xanthine adenosine antagonist.
    Williams et al.
    J.Pharmacol.Exp.Ther., 1987;241:415
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGS 15943 include:

2 Citations: Showing 1 - 2
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  1. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
    Authors: Avanzato Et al.
    Scientific Reports 2016;6:32602
  2. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods 2015;12:661

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