CGS 15943

Catalog # Availability Size / Price Qty
1699/10
1699/50
CGS 15943 | CAS No. 104615-18-1 | Non-selective Adenosine Receptor Antagonists
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Description: Potent adenosine receptor antagonist

Chemical Name: 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Purity: ≥99%

Product Details
Citations (6)
Supplemental Products
Reviews (1)

Biological Activity

CGS 15943 is a potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively). Orally active in vivo.

Technical Data

M.Wt:
285.69
Formula:
C13H8ClN5O
Solubility:
Soluble to 5 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
104615-18-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist.
    Ghai et al.
    J.Pharmacol.Exp.Ther., 1987;242:784
  2. Adenosine receptors and their ligands.
    Klot
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  3. Biochemical characterization of the triazoloquinazoline CGS 15943, a novel, non-xanthine adenosine antagonist.
    Williams et al.
    J.Pharmacol.Exp.Ther., 1987;241:415

Product Datasheets

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Citations for CGS 15943

The citations listed below are publications that use Tocris products. Selected citations for CGS 15943 include:

6 Citations: Showing 1 - 6

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In vivo and in vitro use of CGS 15943
By Ariel Vitenzon on 01/05/2018
Application: Species: Mouse

This compound was used both in vivo and in vitro. For in vivo experiments we injected the compound systemically into transgenic mice and evaluated the effect of the drug on motor behavior. In vitro we used the drug on slices to evaluate the effect on the physiology of cells.


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