CHC
Chemical Name: 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Purity: ≥98%
Biological Activity
CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study.
Colen et al.
Neurosurgery, 2006;59:1313 -
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
Miranda-Gonçalves et al.
Neuro.Oncol., 2013;15:172 -
The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma.
Fang et al.
Mol.Pharmacol., 2006;70:2108 -
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
Dimmer et al.
Biochem.J., 2000;350:219
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for CHC
The citations listed below are publications that use Tocris products. Selected citations for CHC include:
1 Citation: Showing 1 - 1
-
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes Ins resistance.
Authors: Jang Et al.
Nat Med 2016;22:421
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for CHC
There are currently no reviews for this product. Be the first to review CHC and earn rewards!
Have you used CHC?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
