Chemical Name: 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Biological Activity Monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at +4°C
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