Monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo
; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide
(Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.
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All Tocris products are intended for laboratory research use only.
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
Miranda-Gonçalves et al.
The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma.
Fang et al.
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
Dimmer et al.
Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study.
Colen et al.