CHC

Catalog # Availability Size / Price Qty
5029/50
Cat.No. 5029 - CHC | C10H7NO3 | CAS No. 28166-41-8
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Description: MCT inhibitor; decreases glycoloysis

Chemical Name: 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.

Technical Data

M.Wt:
189.17
Formula:
C10H7NO3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
28166-41-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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