Temozolomide

Catalog # Availability Size / Price Qty
2706/10
2706/50
Cat.No. 2706 - Temozolomide | C6H6N6O2 | CAS No. 85622-93-1
1 Image
Description: DNA-methylating antitumor agent
Alternative Names: NSC 362856, CCRG 81045

Chemical Name: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 μM for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).

Technical Data

M.Wt:
194.15
Formula:
C6H6N6O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
85622-93-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells.
    Kanzawa et al.
    Cell Death Differ., 2004;11:448
  2. Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Plowman et al.
    Cancer Res., 1994;54:3793
  3. Antitumor imidazotetraazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.
    Clark et al.
    J.Med.Chem., 1995;38:1493
  4. Formation of DNA adducts and induction of lacI mutations in big blue rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric tumors.
    Bodell et al.
    Cancer Epidemiol.Biomarkers Prevent., 2003;12:545

Product Datasheets

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Citations for Temozolomide

The citations listed below are publications that use Tocris products. Selected citations for Temozolomide include:

5 Citations: Showing 1 - 5

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