Temozolomide

Tocris Bioscience | Catalog # 2706

DNA-methylating antitumor agent
Tocris Bioscience

Key Product Details

Description

DNA-methylating antitumor agent

Alternative Names

NSC 362856,CCRG 81045
View all Apoptosis Inducer Compounds »

Product Description

Temozolomide is a DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 μM for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).

Product Specifications for Temozolomide

Molecular Weight

194.15

Formula

C6H6N6O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

CAS Number

85622-93-1

PubChem ID

5394

InChI Key

BPEGJWRSRHCHSN-UHFFFAOYSA-N

SMILES

CN1N=NC2=C(N=CN2C1=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.71 50

Preparing Stock Solutions for Temozolomide

The following data is based on the product molecular weight 194.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 10.30 mL 51.51 mL 103.01 mL
2.5 mM 2.06 mL 10.30 mL 20.60 mL
5 mM 1.03 mL 5.15 mL 10.30 mL
25 mM 0.21 mL 1.03 mL 2.06 mL

Calculators

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Product Documents for Temozolomide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Temozolomide

For research use only

Customer Reviews for Temozolomide (1)

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  • Generating TMZ-resistant glioma cell lines
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/18/2022
    Temozolomide was used for the establishment of TMZ-resistant glioma cell lines.

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