Chemical Name: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
Biological ActivityDNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 μM for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells.
Kanzawa et al.
Cell Death Differ., 2004;11:448
Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Plowman et al.
Cancer Res., 1994;54:3793
Antitumor imidazotetraazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.
Clark et al.
Formation of DNA adducts and induction of lacI mutations in big blue rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric tumors.
Bodell et al.
Cancer Epidemiol.Biomarkers Prevent., 2003;12:545
Citations for Temozolomide
The citations listed below are publications that use Tocris products. Selected citations for Temozolomide include:
5 Citations: Showing 1 - 5
Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer.
Authors: Canello Et al.
PLoS One 2014;9:e113854
BET bromodomain proteins are required for glioblastoma cell proliferation.
Authors: Pastori Et al.
Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.
Authors: Prabhu Et al.
PLoS One 2013;7:e52265
The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells.
Authors: Johannessen Et al.
Neuro Oncol 2013;15:269
Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
Authors: Hu Et al.
Cancer Res 2012;72:3873
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