Temozolomide

  ( 5 citations )    
Product Datasheet
Catalog Number:2706
Alternate Names:NSC 362856, CCRG 81045
Chemical Name:3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
Product Details
Citations (5)
Reviews
Biological Activity
DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 μM for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).
Technical Data
  • M.Wt:
    194.15
  • Formula:
    C6H6N6O2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    85622-93-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Temozolomide include:

5 Citations: Showing 1 - 5
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  1. Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer.
    Authors: Canello Et al.
    PLoS One  2014;9:e113854
  2. BET bromodomain proteins are required for glioblastoma cell proliferation.
    Authors: Pastori Et al.
    Epigenetics  2014;9:611
  3. Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.
    Authors: Prabhu Et al.
    PLoS One  2013;7:e52265
  4. The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells.
    Authors: Johannessen Et al.
    Neuro Oncol  2013;15:269
  5. Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
    Authors: Hu Et al.
    Cancer Res  2012;72:3873

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