Catalog # Availability Size / Price Qty
Temozolomide | CAS No. 85622-93-1 | Apoptosis Inducer Compounds
1 Image
Description: DNA-methylating antitumor agent
Alternative Names: NSC 362856, CCRG 81045

Chemical Name: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

Purity: ≥99%

Product Details
Citations (6)

Biological Activity

DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 μM for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).

Technical Data

Soluble to 50 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells.
    Kanzawa et al.
    Cell Death Differ., 2004;11:448
  2. Formation of DNA adducts and induction of lacI mutations in big blue rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric tumors.
    Bodell et al.
    Cancer Epidemiol.Biomarkers Prevent., 2003;12:545
  3. Preclinical antitumor activity of temozol. in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Plowman et al.
    Cancer Res., 1994;54:3793
  4. Antitumor imidazotetraazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozol.
    Clark et al.
    J.Med.Chem., 1995;38:1493

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Temozolomide

The citations listed below are publications that use Tocris products. Selected citations for Temozolomide include:

6 Citations: Showing 1 - 6


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Temozolomide

There are currently no reviews for this product. Be the first to review Temozolomide and earn rewards!

Have you used Temozolomide?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.