CITCO

Catalog # Availability Size / Price Qty
3683/10
3683/50
CITCO | CAS No. 338404-52-7 | VDR-like Receptor Agonists
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Description: Selective CAR agonist

Chemical Name: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

Constitutive androstane receptor (CAR) agonist (EC50 = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro.

Technical Data

M.Wt:
436.74
Formula:
C19H12Cl3N3OS
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
338404-52-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.
    Maglich et al.
    J.Biol.Chem., 2003;278:17277
  2. A single amino acid controls the functional switch of human CAR1 to the xenobiotic sensitive splicing variant CAR3.
    Clen et al.
    J.Pharmacol.Exp.Ther., 2009;332:106
  3. Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression.
    Moreau et al.
    Biochem.Biophys.Res.Comm., 2007;360:76

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Citations for CITCO

The citations listed below are publications that use Tocris products. Selected citations for CITCO include:

3 Citations: Showing 1 - 3

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