CITCO

Key Product Details

Product Description

CITCO is a constitutive androstane receptor (CAR) agonist (EC₅₀ = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro.

Product Specifications for CITCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CITCO

The following data is based on the product molecular weight 436.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.58 mL	22.90 mL	45.79 mL
2.5 mM	0.92 mL	4.58 mL	9.16 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
25 mM	0.09 mL	0.46 mL	0.92 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Clen A single amino acid controls the functional switch of human CAR1 to the xenobiotic sensitive splicing variant CAR3. J.Pharmacol.Exp.Ther. 2009 PMID: 19820207
• Moreau Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression. Biochem.Biophys.Res.Comm. 2007 PMID: 17585873
• Maglich Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J.Biol.Chem. 2003 PMID: 12611900

Product Documents for CITCO