Catalog Number: 3683
Chemical Name: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
Biological Activity
Constitutive androstane receptor (CAR) agonist (EC50 = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro.
Technical Data
  • M.Wt:
    436.74
  • Formula:
    C19H12Cl3N3OS
  • Solubility:
    Soluble to 50 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    338404-52-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.
    Maglich et al.
    J.Biol.Chem., 2003;278:17277
  2. A single amino acid controls the functional switch of human CAR1 to the xenobiotic sensitive splicing variant CAR3.
    Clen et al.
    J.Pharmacol.Exp.Ther., 2009;332:106
  3. Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression.
    Moreau et al.
    Biochem.Biophys.Res.Comm., 2007;360:76

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