Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC50
values are 4.7, 1.7, 2700 and 1300 μ
M for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).
Bjerrum et al.
Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist.
Kristensen et al.