Catalog Number: 1673
Alternate Names: 4-Chlorohomoibotenic acid
Chemical Name: (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
Biological Activity
Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively).
Technical Data
  • M.Wt:
    206.59
  • Formula:
    C6H7ClN2O4
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    909400-43-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).
    Bjerrum et al.
    J.Med.Chem., 2003;46:2246
  2. Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist.
    Kristensen et al.
    Soc.Neurosci.Abstr., 2002;:540.7

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