Catalog Number: 4096
Alternate Names: CLT
Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
Biological Activity
Imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).
Technical Data
  • M.Wt:
    344.84
  • Formula:
    C22H17ClN2
  • Solubility:
    Soluble to 75 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    23593-75-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein.
    Lempiainen et al.
    Mol.Endocrinol., 2005;19:2258
  2. Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle.
    Snajdrova et al.
    J.Biol.Chem., 1998;273:28032
  3. Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells.
    Wu et al.
    Neuropharmacology, 1999;38:979
  4. The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes.
    Thomas et al.
    Br.J.Pharmacol., 1999;126:1531

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