Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
Biological ActivityImidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein.
Lempiainen et al.
Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle.
Snajdrova et al.
Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells.
Wu et al.
The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes.
Thomas et al.
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