Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
Biological ActivityClotrimazole is an imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein.
Lempiainen et al.
Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle.
Snajdrova et al.
Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells.
Wu et al.
The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes.
Thomas et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Clotrimazole
There are currently no reviews for this product. Be the first to review Clotrimazole and earn rewards!
Have you used Clotrimazole?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image