Conivaptan hydrochloride

Key Product Details

Product Description

Conivaptan hydrochloride is a very high affinity vasopressin V_1A and V₂ antagonist (K_i values are 0.61 and 0.66 - 3.04 nM, respectively). Inhibits vasopressin-induced pressor responses in rats without altering blood pressure, and increases urine flow while decreasing urine osmolality. Orally bioavailable.

Product Specifications for Conivaptan hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Conivaptan hydrochloride

The following data is based on the product molecular weight 535.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.35 mL	18.69 mL
5 mM	0.37 mL	1.87 mL	3.74 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yatsu Pharmacological profile of YM087, a novel nonpeptide dual vasopressin V_1A and V₂ receptor antagonist, in dogs. Eur.J.Pharmacol. 1997 PMID: 9063692
• Tahara Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V_1A and V₂ receptor antagonist, in vitro and in vivo. J.Pharmacol.Exp.Ther. 1997 PMID: 9223568

Product Documents for Conivaptan hydrochloride