Catalog Number: 2304
Alternate Names: L-364,718, MK 329
Chemical Name: N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
Biological Activity
Potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of intracerebroventricular administration of the CCK1 receptor antagonist devazepide on food intake in rats.
    Eur.J.Pharmacol., 2002;441:79
  2. Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
    Duca et al.
    Nat.Med., 2015;21:506
  3. Effects of peripheral CCK receptor blockade on food intake in rats.
    Reidelberger et al.
    Am.J.Physiol.Reg.Integr.Comp.Physiol., 2003;285:R429
  4. Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents.
    Am.J.Physiol.Reg.Integr.Comp.Physiol., 2004;286:R991
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