Catalog Number: 2304
Alternate Names: L-364,718, MK 329
Chemical Name: N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
Biological Activity
Potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.
Technical Data
  • M.Wt:
    408.46
  • Formula:
    C25H20N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    103420-77-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of intracerebroventricular administration of the CCK1 receptor antagonist devazepide on food intake in rats.
    Ebenezer
    Eur.J.Pharmacol., 2002;441:79
  2. Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
    Duca et al.
    Nat.Med., 2015;21:506
  3. Effects of peripheral CCK receptor blockade on food intake in rats.
    Reidelberger et al.
    Am.J.Physiol.Reg.Integr.Comp.Physiol., 2003;285:R429
  4. Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents.
    Ritter
    Am.J.Physiol.Reg.Integr.Comp.Physiol., 2004;286:R991
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Devazepide include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.
    Authors: D'Agostino Et al.
    BMC Neurosci 2016;5
  2. Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages.
    Authors: Saia Et al.
    Mediators Inflamm 2014;2014:896029
  3. Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.
    Authors: Blevins Et al.
    Am J Physiol Regul Integr Comp Physiol 2012;303:R1231
  4. Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.
    Authors: Wen Et al.
    Front Mol Neurosci 2012;13:63

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