Devazepide

  ( 7 citations )    
Product Datasheet
Catalog Number:2304
Alternate Names:L-364,718, MK 329
Chemical Name:N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
Product Details
Citations (7)
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Biological Activity
Potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.
Technical Data
  • M.Wt:
    408.46
  • Formula:
    C25H20N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    103420-77-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Devazepide include:

7 Citations: Showing 1 - 7
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  1. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.
    Authors: D'Agostino Et al.
    BMC Neurosci  2016;5
  2. Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages.
    Authors: Saia Et al.
    Mediators Inflamm  2014;2014:896029
  3. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.
    Authors: Blouet and Schwartz
    PLoS One  2012;7:e51898
  4. Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.
    Authors: Blevins Et al.
    Am J Physiol Regul Integr Comp Physiol  2012;303:R1231
  5. Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.
    Authors: Wen Et al.
    Front Mol Neurosci  2012;13:63
  6. Ongoing ingestive behavior is rapidly suppressed by a preabsorptive, intestinal itter taste cue.
    Authors: Schier Et al.
    Am J Physiol Regul Integr Comp Physiol  2011;301:R1557
  7. Intestinal cholecystokinin controls glucose production through a neuronal network.
    Authors: Cheung Et al.
    Cell Metab  2009;10:99

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