Catalog # Availability Size / Price Qty
Devazepide | CAS No. 103420-77-5 | CCK1 Receptor Antagonists
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Description: Selective, orally active CCK1 receptor antagonist
Alternative Names: L-364,718, MK 329

Chemical Name: N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products

Biological Activity

Devazepide is a potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Devazepide

The citations listed below are publications that use Tocris products. Selected citations for Devazepide include:

9 Citations: Showing 1 - 9

  1. Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity.
    Authors: Argueta Et al.
    Front Physiol  2019;10:704
  2. Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis.
    Authors: Bauer Et al.
    Cell Metab  2018;27:572
  3. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.
    Authors: D'Agostino Et al.
    BMC Neurosci  2016;5
  4. Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages.
    Authors: Saia Et al.
    Mediators Inflamm  2014;2014:896029
  5. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.
    Authors: Blouet and Schwartz
    PLoS One  2012;7:e51898
  6. Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.
    Authors: Blevins Et al.
    Am J Physiol Regul Integr Comp Physiol  2012;303:R1231
  7. Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular mor. dependence.
    Authors: Wen Et al.
    Front Mol Neurosci  2012;13:63
  8. Ongoing ingestive behavior is rapidly suppressed by a preabsorptive, intestinal "bitter taste" cue.
    Authors: Schier Et al.
    Am J Physiol Regul Integr Comp Physiol  2011;301:R1557
  9. Intestinal cholecystokinin controls glucose production through a neuronal network.
    Authors: Cheung Et al.
    Cell Metab  2009;10:99


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