Devazepide

Catalog # Availability Size / Price Qty
2304/10
2304/50
Devazepide | CAS No. 103420-77-5 | CCK1 Receptor Antagonists
1 Image
Description: Selective, orally active CCK1 receptor antagonist
Alternative Names: L-364,718, MK 329

Chemical Name: N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products
Reviews

Biological Activity

Potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.

Technical Data

M.Wt:
408.46
Formula:
C25H20N4O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
103420-77-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Devazepide

The citations listed below are publications that use Tocris products. Selected citations for Devazepide include:

9 Citations: Showing 1 - 9

  1. Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity.
    Authors: Argueta Et al.
    Front Physiol  2019;10:704
  2. Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis.
    Authors: Bauer Et al.
    Cell Metab  2018;27:572
  3. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.
    Authors: D'Agostino Et al.
    BMC Neurosci  2016;5
  4. Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages.
    Authors: Saia Et al.
    Mediators Inflamm  2014;2014:896029
  5. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.
    Authors: Blouet and Schwartz
    PLoS One  2012;7:e51898
  6. Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.
    Authors: Blevins Et al.
    Am J Physiol Regul Integr Comp Physiol  2012;303:R1231
  7. Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular mor. dependence.
    Authors: Wen Et al.
    Front Mol Neurosci  2012;13:63
  8. Ongoing ingestive behavior is rapidly suppressed by a preabsorptive, intestinal "bitter taste" cue.
    Authors: Schier Et al.
    Am J Physiol Regul Integr Comp Physiol  2011;301:R1557
  9. Intestinal cholecystokinin controls glucose production through a neuronal network.
    Authors: Cheung Et al.
    Cell Metab  2009;10:99

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Devazepide

There are currently no reviews for this product. Be the first to review Devazepide and earn rewards!

Have you used Devazepide?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.