dUTPase Antibody

Novus Biologicals | Catalog # NB100-56624

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all dUTPase Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against a mixture of KLH-conjugated synthetic peptides corresponding to amino acids 25-44 and 113-130 of human dUTPase.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for dUTPase Antibody

Western Blot: dUTPase Antibody [NB100-56624]

Western Blot: dUTPase Antibody [NB100-56624]

Western Blot: dUTPase Antibody [NB100-56624] - Detection of DUT-N in HeLa cell lysate using this antibody at a dilution of 1:1000.

Applications for dUTPase Antibody

Application
Recommended Usage

Western Blot

1:1000-1:2000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.05% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: dUTPase

Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a ubiquitous enzyme that functions in the hydrolysis of dUTP to dUMP and pyrophosphate. Canman and co-workers have demonstrated that, in certain human tumor cell lines, increased levels of dUTPase are responsible for an increase in resistance to the cancer chemotherapeutic agent fluorodeoxyuridine (FUdR), a thymidine synthase inhibitor. Two distinct forms of dUTPase exist in humans. Cellular fractionation experiments suggest that the more abundant, lower mass form of dUTPase (DUT-N) localizes in the nucleus, while the higher mass form (DUT-M) is associated with the mitochondria.

Alternate Names

deoxyuridine triphosphatase, dUTP pyrophosphatasedUTP nucleotidohydrolase, dUTPasedeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, EC 3.6.1.23, FLJ20622

Entrez Gene IDs

1854 (Human)

Gene Symbol

DUT

UniProt

P33316 (Human)

Additional dUTPase Products

Product Documents for dUTPase Antibody

Certificate of Analysis

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Product Specific Notices for dUTPase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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