E 64

  ( 1 citations )    
Product Datasheet
Catalog Number:5208
Chemical Name:(2S,3S)-3-[[[(1S)-1-[[[4-(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
Product Details
Citations (1)
Reviews
Biological Activity
Potent and irreversible cysteine protease inhibitor (IC50 values are 1.4, 2.5 and 4.1 nM for cathepsin K, L and S respectively. Also inhibits papain, calpain, cathepsin B and cathepsin H. Has no effect on serine proteases. Reduces HSC-3 tongue cancer cell invasion and induces oxidative stress and apoptosis in filarial parasites. Also inhibits autophagy-associated lysosomal degradation in vitro.
Technical Data
  • M.Wt:
    357.41
  • Formula:
    C15H27N5O5
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    66701-25-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for E 64 include:

1 Citations: Showing 1 - 1

  1. Tricyclic Antidepressants Amitriptyline and Desipramine Induced Neurotoxicity Associated with Parkinson's Disease.
    Authors: Lee Et al.
    PLoS One  2015;38:734

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