Chemical Name: (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide
Biological ActivityEdelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
Powis et al.
Cancer Res., 1992;52:2835
A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor.
Aoki et al.
Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
Shimizu et al.
Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis.
Wong et al.
BMC Cell Biol., 2007;8:15
Citations for Edelfosine
The citations listed below are publications that use Tocris products. Selected citations for Edelfosine include:
9 Citations: Showing 1 - 9
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.
Authors: Yu Et al.
Nat Commun 2017;8:1457
Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Authors: Pitt Et al.
Mol Biol Cell 2017;28:2623
Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis.
Authors: Ailte Et al.
A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
Authors: Liu Et al.
Sci Signal 2015;8:ra71
NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells.
Authors: Ozkucur Et al.
Cell Mol Life Sci 2014;71:4653
BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.
J Neurophysiol 2014;111:1008
Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
Authors: Korb Et al.
Nat Neurosci 2013;16:874
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Authors: Lee Et al.
Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells.
Authors: Melchior and Frangos
Cancer Biol Ther 2012;303:C467
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