Synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50
= 9.6 μ
M in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.
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All Tocris products are intended for laboratory research use only.
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
Powis et al.
Cancer Res., 1992;52:2835
A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor.
Aoki et al.
Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
Shimizu et al.
Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis.
Wong et al.
BMC Cell Biol., 2007;8:15
The citations listed below are publications that use Tocris products. Selected citations for Edelfosine include:
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