Edelfosine

Tocris Bioscience | Catalog # 3022

Selective PI-PLC inhibitor, also PAF receptor agonist
Tocris Bioscience
Discontinued Product
3022 has been discontinued. An alternative/replacement product is available: 7462. View all Phospholipase Inhibitors products.

Key Product Details

Description

Selective PI-PLC inhibitor, also PAF receptor agonist

Alternative Names

ET-18-OCH3
View all Phospholipase Inhibitors »

Product Description

Edelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.

Product Specifications for Edelfosine

Molecular Weight

523.73

Formula

C27H58NO6P

Storage

Store at -20°C

Chemical Name

(7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide

CAS Number

77286-66-9

PubChem ID

6918215

InChI Key

MHFRGQHAERHWKZ-HHHXNRCGSA-N

SMILES

CO[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.62 5 with gentle warming

Preparing Stock Solutions for Edelfosine

The following data is based on the product molecular weight 523.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 38.19 mL 190.94 mL 381.88 mL
0.25 mM 7.64 mL 38.19 mL 76.38 mL
0.5 mM 3.82 mL 19.09 mL 38.19 mL
2.5 mM 0.76 mL 3.82 mL 7.64 mL

Calculators

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Product Documents for Edelfosine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Edelfosine

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for Edelfosine (1)

4 out of 5
1 Customer Rating
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  • works well
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampal neuron
    Verified Customer | Posted 03/26/2020
    10uM
    Edelfosine 3022

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