Edelfosine (CAS 77286-66-9): R&D Systems
Catalog Number: 3022
Alternate Names: ET-18-OCH3
Chemical Name: (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide
Biological Activity
Synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.
Technical Data
  • M.Wt:
    523.73
  • Formula:
    C27H58NO6P
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 100 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    77286-66-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
    Powis et al.
    Cancer Res., 1992;52:2835
  2. A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor.
    Aoki et al.
    J.Immunol.Methods, 1995;186:225
  3. Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
    Shimizu et al.
    Eur.J.Pharmacol., 2007;571:138
  4. Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis.
    Wong et al.
    BMC Cell Biol., 2007;8:15
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Edelfosine include:

5 Citations: Showing 1 - 5
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  1. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
    Authors: Liu Et al.
    Sci Signal 2015;8:ra71
  2. NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells.
    Authors: Ozkucur Et al.
    Cell Mol Life Sci 2014;71:4653
  3. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
    Authors: Korb Et al.
    Nat Neurosci 2013;16:874
  4. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature 2012;492:123
  5. Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells.
    Authors: Melchior and Frangos
    Cancer Biol Ther 2012;303:C467

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