Edelfosine

  ( 5 citations )    
Product Datasheet
Catalog Number:3022
Alternate Names:ET-18-OCH3
Chemical Name:(7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide
Product Details
Citations (5)
Reviews
Biological Activity
Synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.
Technical Data
  • M.Wt:
    523.73
  • Formula:
    C27H58NO6P
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 100 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    77286-66-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Edelfosine include:

5 Citations: Showing 1 - 5
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  1. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
    Authors: Liu Et al.
    Sci Signal  2015;8:ra71
  2. NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells.
    Authors: Ozkucur Et al.
    Cell Mol Life Sci  2014;71:4653
  3. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
    Authors: Korb Et al.
    Nat Neurosci  2013;16:874
  4. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  5. Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells.
    Authors: Melchior and Frangos
    Cancer Biol Ther  2012;303:C467

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