ET 18-OCH3

Catalog # Availability Size / Price Qty
ET 18-OCH3 | CAS No. 70641-51-9 | Phospholipase C Inhibitors
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Description: Selective PI-PLC inhibitor, also PAF receptor agonist

Chemical Name: 4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium 4-oxide

Product Details

Biological Activity

ET 18-OCH3 is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells). ET 18-OCH3 acts as an agonist at platelet-activating factor (PAF) receptors. ET 18-OCH3 is an antitumor lipid that selectively induces apoptosis in tumor cells, sparing normal cells, and activates the intracellular Fas/CD95 death receptor. ETH 18-OCH3 also triggers eryptosis and interacts with mitochondrial membranes to increase mitochondrial membrane permeability, leading to dysfunction and apoptosis. Racemic mixture.

Technical Data

Soluble to 20 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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