Eliprodil

Tocris Bioscience | Catalog # 2195

Non-competitive and GluN2B-selective NMDA antagonist
Tocris Bioscience
Discontinued Product
2195 has been discontinued. View all NMDA Receptor Antagonists products.

Key Product Details

Description

Non-competitive and GluN2B-selective NMDA antagonist
View all NMDA Receptor Antagonists »

Product Description

Eliprodil is a non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for GluN2B (formally NR2B)- over GluN2A (NR2A)- and GluN2C (NR2C)-containing receptors (IC50 values are 1, > 100 and > 100 μM respectively). Also σ1 ligand (Ki = 0.013 μM). Antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Neuroprotective.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for Eliprodil

Molecular Weight

347.86

Formula

C20H23ClFNO

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol

CAS Number

119431-25-3

PubChem ID

60703

InChI Key

GGUSQTSTQSHJAH-UHFFFAOYSA-N

SMILES

OC(CN1CCC(CC2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.7 25

Preparing Stock Solutions for Eliprodil

The following data is based on the product molecular weight 347.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.50 mL 57.49 mL 114.99 mL
1.25 mM 2.30 mL 11.50 mL 23.00 mL
2.5 mM 1.15 mL 5.75 mL 11.50 mL
12.5 mM 0.23 mL 1.15 mL 2.30 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for Eliprodil

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Eliprodil

For research use only

Customer Reviews for Eliprodil (1)

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  • Evaluate the efficacity and the window of therapeutic opportunity of Eliprodil
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/17/2019
    We studied the histological assessment of the volume of the traumatic brain lesion to estimate the extent of the structural damage. In the study, we have used this approach to evaluate the efficacity and the window of therapeutic opportunity of Eliprodil.
    Eliprodil 2195

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