Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC50
values are 1, > 100 and > 100 μ
M respectively). Also σ1
= 0.013 μ
M). Antagonizes neuronal voltage-gated Ca2+
channels and selectively inhibits the rapid component of the delayed rectifier K+
Soluble to 25 mM in DMSO
Desiccate at +4°C
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All Tocris products are intended for laboratory research use only.
The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia.
Bath et al.
Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk.
Lengyel et al.
Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition.
Whittemore et al.
The citations listed below are publications that use Tocris products. Selected citations for Eliprodil include:
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