Eliprodil

Catalog # Availability Size / Price Qty
2195/10
2195/50
Eliprodil | CAS No. 119431-25-3 | NMDA Receptor Antagonists
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Description: Non-competitive and GluN2B-selective NMDA antagonist

Chemical Name: α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for GluN2B (formally NR2B)- over GluN2A (NR2A)- and GluN2C (NR2C)-containing receptors (IC50 values are 1, > 100 and > 100 μM respectively). Also σ1 ligand (Ki = 0.013 μM). Antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Neuroprotective.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
347.86
Formula:
C20H23ClFNO
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
119431-25-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Eliprodil

The citations listed below are publications that use Tocris products. Selected citations for Eliprodil include:

2 Citations: Showing 1 - 2

  1. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  2. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int  2012;61:601

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Evaluate the efficacity and the window of therapeutic opportunity of Eliprodil
By Anonymous on 12/17/2019
Species: Human

We studied the histological assessment of the volume of the traumatic brain lesion to estimate the extent of the structural damage. In the study, we have used this approach to evaluate the efficacity and the window of therapeutic opportunity of Eliprodil.


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