Embelin

Catalog # Availability Size / Price Qty
2156/10
2156/50
Embelin | CAS No. 550-24-3 | IAP Inhibitors
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Description: Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor

Chemical Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6 μM), but has a weaker effect on normal prostate cells (IC50 = 19 - 20 μM). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo.

Technical Data

M.Wt:
294.39
Formula:
C17H26O4
Solubility:
Soluble to 10 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
550-24-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Embelin

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