Chemical Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
Biological ActivityCell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6 μM), but has a weaker effect on normal prostate cells (IC50 = 19 - 20 μM). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.
Chitra et al.
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
Nikolovska-Coleska et al.
Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor.
Modak et al.
ACS Chem.Biol., 2013;8:1311
Citation for Embelin
The citations listed below are publications that use Tocris products. Selected citations for Embelin include:
1 Citation: Showing 1 - 1
Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis.
Authors: Barbelanne Et al.
Hum Mol Genet 2013;22:2482
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