Eplerenone

Catalog # Availability Size / Price Qty
2397/10
2397/50
Mineralocorticoid Receptor Antagonists Small Molecule
1 Image
Description: Selective mineralocorticoid receptor antagonist
Alternative Names: Inspra, Epoxymexrenone

Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.

Technical Data

M.Wt:
414.5
Formula:
C24H30O6
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
107724-20-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.
    De Gasparo et al.
    J.Pharmacol.Exp.Ther., 1987;240:650
  2. Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
    McMahon and Cunningham
    Curr.Opin.Pharmacol., 2001;1:190

Product Datasheets

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Citations for Eplerenone

The citations listed below are publications that use Tocris products. Selected citations for Eplerenone include:

2 Citations: Showing 1 - 2

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