Catalog Number: 2397
Alternate Names: Inspra, Epoxymexrenone
Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Biological Activity
Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.
Technical Data
  • M.Wt:
    414.5
  • Formula:
    C24H30O6
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    107724-20-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.
    De Gasparo et al.
    J.Pharmacol.Exp.Ther., 1987;240:650
  2. Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
    McMahon and Cunningham
    Curr.Opin.Pharmacol., 2001;1:190
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Eplerenone include:

1 Citations: Showing 1 - 1

  1. Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism.
    Authors: Urbanet Et al.
    Purinergic Signal 2010;95:4037

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