Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Biological ActivityEplerenone is a selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.
De Gasparo et al.
Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
McMahon and Cunningham
Citations for Eplerenone
The citations listed below are publications that use Tocris products. Selected citations for Eplerenone include:
2 Citations: Showing 1 - 2
Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain.
Authors: Ibrahim Et al.
Front Cell Neurosci 2018;12:453
Analysis of Ins sensitivity in adipose tissue of patients with primary aldosteronism.
Authors: Urbanet Et al.
Purinergic Signal 2010;95:4037
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