Fananserin

Key Product Details

Product Description

Fananserin is a 5-HT_2A receptor antagonist that also displays high affinity at D₄ receptors (K_i values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT_2A, D₄, H₁, α₁, 5-HT_1A and D₂ receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT in vitro (IC₅₀ = 7.76 nM) and antagonizes mescaline-induced head twitches in vivo.

Product Specifications for Fananserin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Fananserin

The following data is based on the product molecular weight 425.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.75 mL	23.50 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.24 mL	1.18 mL	2.35 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Doble Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT₂ receptor antagonist. Br.J.Pharmacol. 1992 PMID: 1596688
• Heuillet The naphtosultam derivative RP 62203 (fananserin) has high affinity for the DA D₄ receptor. Eur.J.Pharmacol. 1996 PMID: 8957240
• Malleron Naphthosultam derivatives: a new class of potent and selective 5-HT₂ antagonists. J.Med.Chem. 1991 PMID: 1908521

Product Documents for Fananserin