Catalog Number: 2645
Alternate Names: RP 62203
Chemical Name: 2-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphthyl[1,8-cd]isothiazole-1,1-dioxide
Biological Activity
5-HT2A receptor antagonist that also displays high affinity at D4 receptors (Ki values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT2A, D4, H1, α1, 5-HT1A and D2 receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT in vitro (IC50 = 7.76 nM) and antagonizes mescaline-induced head twitches in vivo.
Technical Data
  • M.Wt:
    425.52
  • Formula:
    C23H24FN3O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    127625-29-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.
    Malleron et al.
    J.Med.Chem., 1991;34:2477
  2. Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist.
    Doble et al.
    Br.J.Pharmacol., 1992;105:27
  3. The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor.
    Heuillet et al.
    Eur.J.Pharmacol., 1996;314:229

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