Fexaramine

Key Product Details

Product Description

Fexaramine is a potent, selective farnesoid X receptor agonist (EC₅₀ = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.

Product Specifications for Fexaramine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Fexaramine

The following data is based on the product molecular weight 496.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.07 mL	20.14 mL
5 mM	0.40 mL	2.01 mL	4.03 mL
10 mM	0.20 mL	1.01 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Downes A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol.Cell 2003 PMID: 12718892
• Pellicciari Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. J.Med.Chem. 2006 PMID: 16821780
• Nicolaou Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org.Biomol.Chem. 2003 PMID: 12929628

Product Documents for Fexaramine