Catalog Number: 2563
Chemical Name: 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester
Biological Activity
Potent, selective farnesoid X receptor agonist (EC50 = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.
Technical Data
  • M.Wt:
    496.64
  • Formula:
    C32H36N2O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    574013-66-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.
    Nicolaou et al.
    Org.Biomol.Chem., 2003;1:908
  2. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
    Downes et al.
    Mol.Cell, 2003;11:1079
  3. Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.
    Pellicciari et al.
    J.Med.Chem., 2006;49:4208
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fexaramine include:

1 Citations: Showing 1 - 1

  1. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.
    Authors: Nagiec Et al.
    J Endocrinol 2015;10:e0120295

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