Potent, selective farnesoid X receptor agonist (EC50
= 25 nM). Displays no activity at hRXRα
, mPXR, hPXR, hLXRα
, mCAR, mERRγ
and hVDR receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.
Nicolaou et al.
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
Downes et al.
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.
Pellicciari et al.
The citations listed below are publications that use Tocris products. Selected citations for Fexaramine include:
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