Chemical Name: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Biological ActivityFlumazenil is a benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors. Centrally active upon systemic administration in vivo. Also inhibits repressor element-1 silencing transcription factor (REST) by targeting degradation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABAA receptors.
Atack et al.
New insights into the mechanism of action of hypnotics.
Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788.
Polc et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1981;316:317
Citations for Flumazenil
The citations listed below are publications that use Tocris products. Selected citations for Flumazenil include:
7 Citations: Showing 1 - 7
Structure of a human synaptic GABAA receptor.
Local GABAA receptor mediated suppression of DA release within the nucleus accumbens.
Authors: Brodnik Et al.
ACS Chem Neurosci 2018;17:1978
Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.
Authors: Joensuu Et al.
PLoS One 2014;9:e89321
SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.
Authors: Heidelberg Et al.
J Pharmacol Exp Ther 2013;347:235
An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test.
Authors: Carlile Et al.
Life Sci 2012;90:267
Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations.
Authors: Leppä Et al.
PLoS One 2011;6:e24159
Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors.
Authors: Linden Et al.
Front Neurosci 2011;5:3
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