Flumazenil

Catalog # Availability Size / Price Qty
1328/10
1328/50
Flumazenil | CAS No. 78755-81-4 | GABA-A Receptor Benzodiazepines
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Description: Benzodiazepine antagonist
Alternative Names: Ro 15-1788

Chemical Name: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

Purity: ≥99%

Product Details
Citations (7)
Reviews (2)

Biological Activity

Flumazenil is a benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors. Centrally active upon systemic administration in vivo. Also inhibits repressor element-1 silencing transcription factor (REST) by targeting degradation.

Technical Data

M.Wt:
303.29
Formula:
C15H14FN3O3
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
78755-81-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Flumazenil

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Antagonism of Flumazenil to effects of Phenazepam
By Anonymous on 04/14/2020
Application: Species: Other

Flumazenil (FMZ) was used to block action of other benzodiazepine ligand of GABA-A receptor (Phenazepam, PNZ) on decay kinetics of spontaneous inhibitory currents recorded from brain neurons of Prussian carp (Carassius gibelio). FMZ demonstrated competitive antagonism to PNZ in this research, both in vivo (behavioral tests) and in vitro (whole-cell voltage-clamp recordings, see example illustration).

PMID: 29191862

Flumazenil and in vivo chloride signals
By Anonymous on 05/23/2019
Application: Species: Mouse

used with fiber photometry to validate a chloride sensor in vivo. response to footshock was measured at baseline and then at 15 min intervals post injection


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