Catalog Number: 1328
Alternate Names: Ro 15-1788
Chemical Name: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Biological Activity
Benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors. Centrally active upon systemic administration in vivo.
Technical Data
  • M.Wt:
    303.29
  • Formula:
    C15H14FN3O3
  • Solubility:
    Soluble to 25 mM in DMSO and to 5 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    78755-81-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABAA receptors.
    Atack et al.
    Neuropsychopharmacology, 1999;20:255
  2. New insights into the mechanism of action of hypnotics.
    Dobl
    J.Psychopharmacol., 1999;13:S11
  3. Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788.
    Polc et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1981;316:317
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Flumazenil include:

4 Citations: Showing 1 - 4
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  1. Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.
    Authors: Joensuu Et al.
    PLoS One 2014;9:e89321
  2. SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.
    Authors: Heidelberg Et al.
    J Pharmacol Exp Ther 2013;347:235
  3. Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations.
    Authors: Leppä Et al.
    PLoS One 2011;6:e24159
  4. Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors.
    Authors: Linden Et al.
    Front Neurosci 2011;5:3

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