Catalog Number: 1328
Alternate Names: Ro 15-1788
Chemical Name: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Biological Activity
Benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors. Centrally active upon systemic administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO and to 5 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABAA receptors.
    Atack et al.
    Neuropsychopharmacology, 1999;20:255
  2. New insights into the mechanism of action of hypnotics.
    J.Psychopharmacol., 1999;13:S11
  3. Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788.
    Polc et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1981;316:317
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