Fostriecin sodium salt

Catalog # Availability Size / Price Qty
Fostriecin sodium salt | CAS No. 87860-39-7 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Potent PP2A and PP4 inhibitor

Chemical Name: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt

Purity: ≥98%

Product Details
Citations (7)
Reviews (3)

Biological Activity

Fostriecin sodium salt is a potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

Technical Data

Soluble to 100 mM in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Average Rating: 4.3 (Based on 3 Reviews)

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reliable product
By Anonymous on 04/04/2020
Application: Species: Rat

fostriecin for PP2A/4 (Fos, 1 μM)

PMID: 31291571 Reference

Fostriecin increases phosphorylation of CaMKII in HL-1 cells
By Anonymous on 05/15/2019
Application: Species: Mouse

HL-1 cardiomyocytes were treated with 100 nM fostriecin, 100 nM Okadaic acid or 50 nM 8-bromo-cAMP for 30 min followed by Western blot analysis for pCaMKII expression. Fostriecin slightly increased phosphorylation of CaMKII; indicating role of PP2A in CaMKII dephosphorylation.

PP2A dependent dephosphorylation of an enzyme
By Anonymous on 12/04/2017
Application: Species: Rat

I used fostriecin to investigate the contribution of PP2A to dephosphorylation of my enzyme. I preincubated cells with fostriecin and assayed for enzyme activity.

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