Fostriecin sodium salt

Tocris Bioscience | Catalog # 1840

Potent PP2A and PP4 inhibitor
Tocris Bioscience
Discontinued Product
1840 has been discontinued. View all Protein Ser/Thr Phosphatase Inhibitors products.

Key Product Details

Description

Potent PP2A and PP4 inhibitor
View all Protein Ser/Thr Phosphatase Inhibitors »

Product Description

Fostriecin sodium salt is a potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

Product Specifications for Fostriecin sodium salt

Molecular Weight

452.37

Formula

C19H26O9PNa

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt

CAS Number

87860-39-7

PubChem ID

16759606

InChI Key

XBUIKNRVGYFSHL-IAVQPKKASA-M

SMILES

[Na+].C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.24 100

Preparing Stock Solutions for Fostriecin sodium salt

The following data is based on the product molecular weight 452.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.11 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Product Documents for Fostriecin sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fostriecin sodium salt

For research use only

Related Research Areas

Epigenetics
Phosphatases and Regulators

Citations for Fostriecin sodium salt

Customer Reviews for Fostriecin sodium salt (3)

4.3 out of 5
3 Customer Ratings
5 Stars
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4 Stars
67%
3 Stars
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1 Stars
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  • reliable product
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    fostriecin for PP2A/4 (Fos, 1 μM)
    Fostriecin sodium salt 1840
  • Fostriecin increases phosphorylation of CaMKII in HL-1 cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 05/15/2019
    HL-1 cardiomyocytes were treated with 100 nM fostriecin, 100 nM Okadaic acid or 50 nM 8-bromo-cAMP for 30 min followed by Western blot analysis for pCaMKII expression. Fostriecin slightly increased phosphorylation of CaMKII; indicating role of PP2A in CaMKII dephosphorylation.
    Fostriecin sodium salt 1840
  • PP2A dependent dephosphorylation of an enzyme
    Name: Anonymous
    Assay Type: In Vitro
    Cell Line/Tissue: Rat chondrosarcoma (RCS) cells
    Verified Customer | Posted 12/04/2017
    I used fostriecin to investigate the contribution of PP2A to dephosphorylation of my enzyme. I preincubated cells with fostriecin and assayed for enzyme activity.

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