Catalog Number: 1840
Chemical Name: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt
Biological Activity
Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.
Technical Data
  • M.Wt:
    452.37
  • Formula:
    C19H26O9PNa
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    87860-39-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties.
    Tunac et al.
    J.Antibiot., 1983;36:1595
  2. Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.
    Walsh et al.
    FEBS Lett., 1997;416:230
  3. Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.
    Hastie and Cohen
    FEBS Lett., 1998;431:357
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fostriecin sodium salt include:

4 Citations: Showing 1 - 4
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  1. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    J Neurosci 2013;33:15879
  2. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    J Neurosci 2010;30:2935
  3. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.
    Authors: Xu Et al.
    J Neurosci 2010;115:1643
  4. Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.
    Authors: Xu Et al.
    J Neurosci 2009;29:14086
Average Rating: 4 (Based on 1 review)

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