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Fostriecin sodium salt

  ( 5 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1840
Chemical Name:(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt
Product Details
Citations (5)
Reviews
Biological Activity
Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.
Technical Data
  • M.Wt:
    452.37
  • Formula:
    C19H26O9PNa
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    87860-39-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Average Rating: 4 (Based on 1 review)

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