Fostriecin sodium salt

Catalog # Availability Size / Price Qty
1840/50U
Cat.No. 1840 - Fostriecin sodium salt | C19H26O9PNa | CAS No. 87860-39-7
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Description: Potent PP2A and PP4 inhibitor

Chemical Name: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt

Purity: ≥98%

Product Details
Citations (6)
Reviews (1)

Biological Activity

Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

Technical Data

M.Wt:
452.37
Formula:
C19H26O9PNa
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
87860-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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PP2A dependent dephosphorylation of an enzyme
By Anonymous on 12/04/2017
Species: Rat

I used fostriecin to investigate the contribution of PP2A to dephosphorylation of my enzyme. I preincubated cells with fostriecin and assayed for enzyme activity.


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