Gambogic acid

  ( 2 citations )    
Product Datasheet
Catalog Number:3590
Chemical Name:(2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid
Product Details
Citations (2)
Reviews
Biological Activity
Apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC50 values are 0.78 - 1.64 μM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Reverses gefitinib-resistance in mice bearing tumors with EGFR-T790M mutation. Also blocks Kir2.1 channels (EC50 ≤ 100 nM).
Technical Data
  • M.Wt:
    628.75
  • Formula:
    C38H44O8
  • Solubility:
    Soluble to 75 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    2752-65-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Gambogic acid include:

2 Citations: Showing 1 - 2
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  1. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.
    Authors: Tan Et al.
    Proc Natl Acad Sci U S A  2015;13:2039
  2. Label-free cytotoxicity screening assay by digital holographic microscopy.
    Authors: Kühn Et al.
    Assay Drug Dev Technol  2013;11:101

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