Gambogic acid

Tocris Bioscience | Catalog # 3590

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
Tocris Bioscience
Discontinued Product
3590 has been discontinued. View all Apoptosis Inducer Compounds products.

Key Product Details

Description

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
View all Apoptosis Inducer Compounds »

Product Description

Gambogic acid is an apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC50 values are 0.78 - 1.64 μM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Reverses gefitinib-resistance in mice bearing tumors with EGFR-T790M mutation. Also blocks Kir2.1 channels (EC50 ≤ 100 nM).

Product Specifications for Gambogic acid

Molecular Weight

628.75

Formula

C38H44O8

Storage

Store at -20°C

Chemical Name

(2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid

CAS Number

2752-65-0

PubChem ID

15559465

InChI Key

GEZHEQNLKAOMCA-MYCCNKBCSA-N

SMILES

C/C(C)=C/CC[C@@](C=C2)(C)OC1=C2C(O)=C(C(C([C@]45O3)=C[C@H](C[C@@H]56)C([C@](OC(C)6C)4C/C=C(C(O)=O)/C)=O)=O)C3=C1C/C=C(C)/C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.16 75
Ethanol 62.87 100

Preparing Stock Solutions for Gambogic acid

The following data is based on the product molecular weight 628.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.95 mL 15.90 mL
5 mM 0.32 mL 1.59 mL 3.18 mL
10 mM 0.16 mL 0.80 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

Product Documents for Gambogic acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Gambogic acid

For research use only

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