Gambogic acid

Catalog # Availability Size / Price Qty
3590/10
3590/50
Gambogic acid | CAS No. 2752-65-0 | Apoptosis Inducer Compounds
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Description: Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins

Chemical Name: (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid

Product Details
Citations (3)
Reviews

Biological Activity

Apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC50 values are 0.78 - 1.64 μM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Reverses gefitinib-resistance in mice bearing tumors with EGFR-T790M mutation. Also blocks Kir2.1 channels (EC50 ≤ 100 nM).

Technical Data

M.Wt:
628.75
Formula:
C38H44O8
Solubility:
Soluble to 75 mM in DMSO and to 100 mM in ethanol
Storage:
Store at -20°C
CAS No:
2752-65-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Gambogic acid

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3 Citations: Showing 1 - 3

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