Chemical Name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Biological ActivityIressa is an orally active, selective inhibitor of EGFR tyrosine kinase (IC50 = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. Also inhibits growth of brain metastases in mouse model of non-small cell lung cancer.
View information regarding the usage of Iressa for non-clinical studies.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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- Information regarding the use of Iressa for non-clinical studies
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.
Ciardiello et al.
Clin.Cancer Res., 2000;6:2053
ZD1839 ('Iressa'), as an anticancer agent.
Baselga et al.
Tumor penetration of gefi. (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor.
McKillop et al.
Mol.Cancer Ther., 2005;4:641
Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: A direct comparative analysis of icotinib, gefitinib, and erlo. in a nude mouse model.
Tan et al.
Citations for Iressa
The citations listed below are publications that use Tocris products. Selected citations for Iressa include:
21 Citations: Showing 1 - 10
Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling.
Authors: Suina Et al.
Cancer Sci 2018;109:3874
Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.
Authors: Kurimoto Et al.
Oncol Rep 2016;48:1825
Anticancer Effects of Paris Saponins by Apoptosis and PI3K/AKT Pathway in Gefitinib-Resistant Non-Small Cell Lung Cancer.
Authors: Zhu Et al.
Med Sci Monit 2016;22:1435
Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro.
Authors: Staberg Et al.
Cancer Cell Int 2016;16:34
Architecture of Chimeric Spheroids Controls Drug Transport.
Authors: Curran Et al.
Cancer Microenviron 2015;8:101
ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
Authors: Bill Et al.
PLoS One 2015;6:9173
MetF. attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway.
Authors: Li Et al.
Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-κB Activity.
Authors: Lindholm Et al.
J Clin Cell Immunol 2015;6
CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells.
Authors: Moody Et al.
J Mol Neurosci 2015;56:663
Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefi.
Authors: Wang Et al.
An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.
Authors: Kleczko Et al.
Life Sci 2015;10:e0123600
Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630.
Authors: Sakurai Et al.
PLoS One 2014;9:e100124
Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging.
Authors: Qawasmi Et al.
Front Pharmacol 2014;5:257
MetF. sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal.
Authors: Li Et al.
Clin Cancer Res 2014;20:2714
Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.
Authors: Joannes Et al.
J Biol Chem 2014;12:775
SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner.
Authors: Moody Et al.
Mol Cancer Res 2014;100:25
Role for the epidermal growth factor receptor in chemotherapy-induced alopecia.
Authors: Bichsel Et al.
PLoS One 2013;8:e69368
Effect of MetF. on residual cells after chemotherapy in a human lung adenocarcinoma cell line.
Authors: Kitazono Et al.
Int J Oncol 2013;43:1846
Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma.
Authors: Edris Et al.
Stathmin is involved in the cooperative effect of zoled. acid and gefi. on bone homing breast cancer cells in vitro.
Authors: Oda Et al.
J Bone Oncol 2012;1:40
Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection.
Authors: McMellen Et al.
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