Chemical Name: N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Biological ActivityOrally active, selective inhibitor of EGFR tyrosine kinase (IC50 = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. Also inhibits growth of brain metastases in mouse model of non-small cell lung cancer.
View information regarding the usage of Iressa for non-clinical studies.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
- Information regarding the use of Iressa for non-clinical studies
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.
Ciardiello et al.
Clin.Cancer Res., 2000;6:2053
ZD1839 ('Iressa'), as an anticancer agent.
Baselga et al.
Tumor penetration of gefi. (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor.
McKillop et al.
Mol.Cancer Ther., 2005;4:641
Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: A direct comparative analysis of icotinib, gefitinib, and erlo. in a nude mouse model.
Tan et al.
Citations for Iressa
The citations listed below are publications that use Tocris products. Selected citations for Iressa include:
21 Citations: Showing 1 - 10
Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling.
Authors: Suina Et al.
Cancer Sci 2018;109:3874
Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.
Authors: Kurimoto Et al.
Oncol Rep 2016;48:1825
Anticancer Effects of Paris Saponins by Apoptosis and PI3K/AKT Pathway in Gefitinib-Resistant Non-Small Cell Lung Cancer.
Authors: Zhu Et al.
Med Sci Monit 2016;22:1435
Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro.
Authors: Staberg Et al.
Cancer Cell Int 2016;16:34
Architecture of Chimeric Spheroids Controls Drug Transport.
Authors: Curran Et al.
Cancer Microenviron 2015;8:101
ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
Authors: Bill Et al.
PLoS One 2015;6:9173
MetF. attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway.
Authors: Li Et al.
Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-κB Activity.
Authors: Lindholm Et al.
J Clin Cell Immunol 2015;6
CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells.
Authors: Moody Et al.
J Mol Neurosci 2015;56:663
Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefi.
Authors: Wang Et al.
An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.
Authors: Kleczko Et al.
Life Sci 2015;10:e0123600
Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630.
Authors: Sakurai Et al.
PLoS One 2014;9:e100124
Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging.
Authors: Qawasmi Et al.
Front Pharmacol 2014;5:257
MetF. sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal.
Authors: Li Et al.
Clin Cancer Res 2014;20:2714
Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.
Authors: Joannes Et al.
J Biol Chem 2014;12:775
SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner.
Authors: Moody Et al.
Mol Cancer Res 2014;100:25
Role for the epidermal growth factor receptor in chemotherapy-induced alopecia.
Authors: Bichsel Et al.
PLoS One 2013;8:e69368
Effect of MetF. on residual cells after chemotherapy in a human lung adenocarcinoma cell line.
Authors: Kitazono Et al.
Int J Oncol 2013;43:1846
Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma.
Authors: Edris Et al.
Stathmin is involved in the cooperative effect of zoled. acid and gefi. on bone homing breast cancer cells in vitro.
Authors: Oda Et al.
J Bone Oncol 2012;1:40
Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection.
Authors: McMellen Et al.
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