( 15 citations )    
Product Datasheet
Catalog Number:3000
Alternate Names:Gefitinib, ZD 1839
Chemical Name:N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Product Details
Citations (15)
Supplemental Products
Biological Activity
Orally active, selective inhibitor of EGFR tyrosine kinase (IC50 = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. Also inhibits growth of brain metastases in mouse model of non-small cell lung cancer.

View information regarding the usage of Iressa for non-clinical studies.

Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes only under agreement from AstraZeneca
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The citations listed below are publications that use Tocris products. Selected citations for Iressa include:

15 Citations: Showing 1 - 10
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  1. Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.
    Authors: Kurimoto Et al.
    Oncol Rep  2016;48:1825
  2. Anticancer Effects of Paris Saponins by Apoptosis and PI3K/AKT Pathway in Gefitinib-Resistant Non-Small Cell Lung Cancer.
    Authors: Zhu Et al.
    Med Sci Monit  2016;22:1435
  3. Architecture of Chimeric Spheroids Controls Drug Transport.
    Authors: Curran Et al.
    Cancer Microenviron  2015;8:101
  4. ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
    Authors: Bill Et al.
    PLoS One  2015;6:9173
  5. Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-κB Activity.
    Authors: Lindholm Et al.
    J Clin Cell Immunol  2015;6
  6. CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells.
    Authors: Moody Et al.
    J Mol Neurosci  2015;56:663
  7. Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib.
    Authors: Wang Et al.
    Oncotarget  2015;33:526
  8. An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.
    Authors: Kleczko Et al.
    Life Sci  2015;10:e0123600
  9. Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630.
    Authors: Sakurai Et al.
    PLoS One  2014;9:e100124
  10. Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging.
    Authors: Qawasmi Et al.
    Front Pharmacol  2014;5:257
  11. Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.
    Authors: Joannes Et al.
    J Biol Chem  2014;12:775
  12. SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner.
    Authors: Moody Et al.
    Mol Cancer Res  2014;100:25
  13. Role for the epidermal growth factor receptor in chemotherapy-induced alopecia.
    Authors: Bichsel Et al.
    PLoS One  2013;8:e69368
  14. Effect of metformin on residual cells after chemotherapy in a human lung adenocarcinoma cell line.
    Authors: Kitazono Et al.
    Int J Oncol  2013;43:1846
  15. Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection.
    Authors: McMellen Et al.
    Surgery  2010;148:364
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