Potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (Kd
= 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β
-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.
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Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
Perry et al.
Receptors for glucagon-like peptide-1(7-37) amide on rat insulinoma-derived cells.
Goke and Conlon
A role for glucagon-like peptide-1 in the central regulation of feeding.
Turton et al.
Glucagon-like peptide-1: a major regulator of pancreatic β-cell function.
Perfetti and Merkel