Glucagon-like peptide 1 (7-36) amide (human, rat)
Biological ActivityGlucagon-like peptide 1 (7-36) amide (human, rat) is a potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (Kd = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.
(Modifications: Arg-30 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Receptors for glucagon-like peptide-1(7-37) amide on rat Insoma-derived cells.
Goke and Conlon
A role for glucagon-like peptide-1 in the central regulation of feeding.
Turton et al.
Glucagon-like peptide-1: a major regulator of pancreatic β-cell function.
Perfetti and Merkel
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
Perry et al.
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