Selective dopamine D3
receptor antagonist and D2
partial agonist (pEC50
values are <5.5 and 8.3 respectively). Selective against the D4
receptor in both agonist and antagonist assays. Brain penetrant.
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All Tocris products are intended for laboratory research use only.
The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure.
Holmes et al.