GSK 789472 hydrochloride
Chemical Name: 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
Biological ActivitySelective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The identification of a selective DA D2 partial agonist, D3 antagonist displaying high levels of brain exposure.
Holmes et al.
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VersaClone cDNA Plasmids
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