Chemical Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide
Biological ActivityGue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer
Blättermann et al.
Citation for Gue 1654
The citations listed below are publications that use Tocris products. Selected citations for Gue 1654 include:
1 Citation: Showing 1 - 1
Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors.
Mol Biol Cell 2017;28(24):3554
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VersaClone cDNA Plasmids
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