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Gue 1654

Catalog #: 4742
1 Citation Datasheet / COA / SDS

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4742 has been discontinued.
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Gue 1654 | CAS No. 397290-30-1 | G Protein (Heterotrimeric) Inhibitors
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Description: Selective inhibitor of OXE-R Gβ/γ signaling

Chemical Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide

Purity: ≥97%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.

Technical Data

M.Wt:
447.6
Formula:
C23H17N3OS3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
397290-30-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer
    Blättermann et al.
    Nat.Chem.Biol., 2012;8:631

Product Datasheets

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Citation for Gue 1654

The citations listed below are publications that use Tocris products. Selected citations for Gue 1654 include:

1 Citation: Showing 1 - 1

  1. Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors.
    Authors: Nogueras-Ortiz
    Mol Biol Cell  2017;28(24):3554

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