Oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ
but not Gαi
signaling upon activation of the Gαi
heterotrimer by OXE-R. Inhibits Gβγ
-mediated opening of GIRK1/2 channels in HEK293 cells.
Soluble to 50 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer
Blättermann et al.