HLA DR/DP Antibody (HL-38) [FITC]

Novus Biologicals | Catalog # NB500-407

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Porcine

Applications

Flow Cytometry

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # HL-38
View all HLA DR/DP Primary Antibodies »

Product Specifications

Immunogen

Raji Burkitt's lymphoma cell line

Epitope

This antibody binds to a common epitope on the b-chain of human HLA-DR and HLA-DP.

Specificity

The antibody HL-38 recognizes common epitope on beta-chain of human HLA-DR and HLA-DP. DR and DP are the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for HLA DR/DP Antibody (HL-38) [FITC]

Flow Cytometry: HLA DR/DP Antibody (HL-38) [FITC] [NB500-407] - Surface staining of human peripheral blood with anti-HLA-DR+DP (HL-38) FITC.

Applications for HLA DR/DP Antibody (HL-38) [FITC]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 ul reagent / 100 ul of whole blood or 106 cells in a suspension.

Spectra Viewer

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Size Exclusion Chromatography

Formulation

Phosphate buffered saline (PBS), pH 7.4

Preservative

15mM Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: HLA DR/DP

Human MHC class II antigens are transmembrane glycoproteins composed of an alpha (36 kDa) and a beta chain (27kDa) and are expressed primarily on antigen presenting cells. Human MHC class II genes are located in the HLA-D region that encodes at least 6 alpha and 10 beta chain genes. Three loci, DR, DQ and DP, encode the major products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells and therefore have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.

Alternate Names

FLJ51114, histocompatibility antigen HLA-DR alpha, HLA class II histocompatibility antigen, DR alpha chain, HLA-DRA1, major histocompatibility complex, class II, DR alpha, MHC cell surface glycoprotein, MHC class II antigen DRA, MLRW

Gene Symbol

HLA-DRA

Additional HLA DR/DP Products

Product Documents for HLA DR/DP Antibody (HL-38) [FITC]

Certificate of Analysis

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Product Specific Notices for HLA DR/DP Antibody (HL-38) [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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