Human Active MMP-1 Fluorokine E Kit

Contains Mercury, Dispose According to Local, State or Federal Laws
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Citations (11)
Reviews (2)

Human Active MMP-1 Fluorokine E Kit Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

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Background: MMP-1

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

Long Name
Matrix Metalloproteinase 1
Entrez Gene IDs
4312 (Human); 83995 (Mouse)
Alternate Names
CLGmatrix metalloprotease 1; CLGN; EC 3.4.24; EC; Fibroblast collagenase; interstitial collagenase; matrix metallopeptidase 1 (interstitial collagenase); matrix metalloproteinase 1 (interstitial collagenase); Matrix metalloproteinase-1; MMP1; MMP-1
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to

Citations for Human Active MMP-1 Fluorokine E Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

11 Citations: Showing 1 - 10
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  1. Syringaresinol Inhibits UVA-Induced MMP-1 Expression by Suppression of MAPK/AP-1 Signaling in HaCaT Keratinocytes and Human Dermal Fibroblasts
    Authors: JH Oh, YH Joo, F Karadeniz, J Ko, CS Kong
    Int J Mol Sci, 2020;21(11):.  2020
  2. hsa-miR-100-5p, an overexpressed miRNA in human ovarian endometriotic stromal cells, promotes invasion through attenuation of SMARCD1 expression
    Authors: K Takebayash, K Nasu, M Okamoto, Y Aoyagi, T Hirakawa, H Narahara
    Reprod. Biol. Endocrinol., 2020;18(1):31.  2020
  3. Horse Oil Mitigates Oxidative Damage to Human HaCaT Keratinocytes Caused by Ultraviolet B Irradiation
    Authors: MJ Piao, KA Kang, AX Zhen, HK Kang, YS Koh, BS Kim, JW Hyun
    Int J Mol Sci, 2019;20(6):.  2019
  4. MMP-1 Activation Contributes to Airway Smooth Muscle Growth and Asthma Severity
    Authors: Shams-Un-Nisa Naveed
    Am. J. Respir. Crit. Care Med, 2016;0(0):.  2016
  5. Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line
    Mol Med Rep, 2016;14(4):2937-44.  2016
  6. The effect of local hyperglycemia on skin cells in�vitro and on wound healing in euglycemic rats
    Authors: Carla R Kruse
    J. Surg. Res, 2016;206(2):418-426.  2016
  7. Host gene-encoded severe lung TB: from genes to the potential pathways.
    Authors: Ganachari, M, Guio, H, Zhao, N, Flores-Villanueva, P O
    Genes Immun, 2012;13(8):605-20.  2012
  8. Differential impact of oleate, palmitate, and adipokines on expression of NF-kappaB target genes in human vascular smooth muscle cells.
    Authors: Lamers D, Schlich R, Horrighs A, Cramer A, Sell H, Eckel J
    Mol Cell Endocrinol, 2012;362(1):194-201.  2012
  9. TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease.
    Authors: Geraghty P, Dabo AJ, D'Armiento J
    J. Biol. Chem., 2011;286(34):30211-8.  2011
  10. Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes.
    Authors: Lee YR, Kweon SH, Kwon KB, Park JW, Yoon TR, Park BH
    Biochem. Biophys. Res. Commun., 2009;378(1):90-4.  2009
  11. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion.
    Authors: Singh S, Singh UP, Grizzle WE, Lillard JW
    Lab. Invest., 2004;84(12):1666-76.  2004


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Human Active MMP-1 Fluorokine E Kit
By Leslie Priddy on 04/04/2018

Human Active MMP-1 Fluorokine E Kit
By Boubacar Barry on 08/11/2017