Human Ferroportin/SLC40A1 Alexa Fluor® 700-conjugated Antibody

Recombinant Monoclonal Antibody
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Human Ferroportin/SLC40A1 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity
Detects human Ferroportin/SLC40A1 in direct ELISAs.
Recombinant Monoclonal Rabbit IgG Clone # 1308C
Protein A or G purified from cell culture supernatant
Synthetic peptide containing human Ferroportin/SLC40A1
Accession # Q9NP59
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

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Recommended Concentration
Flow Cytometry
0.25-1 µg/106 cells
HEK293 Human Cell Line Transfected with Human Ferroportin/SLC40A1 and eGFP

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Ferroportin/SLC40A1

Ferroportin-1 (FPN1), also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a multi-pass membrane protein that in humans is encoded by the SLC40A1 gene and is part of the Ferroportin (Fpn) Family. Ferroportin 1 is an iron-regulated transporter that is essential for iron homeostasis, playing a key role in intestinal iron absorption, as well as cellular iron release and efflux. Ferroportin can be regulated at many different levels including transcriptionally, post-transcriptionally, through mRNA stability and post-translationally, through protein turnover. Mutations affecting the SLC40A1 gene result in a disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy and arthritis.

Long Name
Solute Carrier Family 40 Member 1
Entrez Gene IDs
30061 (Human); 53945 (Mouse); 170840 (Rat)
Alternate Names
Ferroportin; Ferroportin-1; FPN1; FPN1IREG1ferroportin 1; HFE4; HFE4ferroportin-1; IREG1; iron regulated gene 1; Iron-regulated transporter 1; member 3; MST079; MSTP079; MTP1; putative ferroportin 1 variant IIIB; SLC11A3; SLC11A3iron regulated gene 1; SLC40A1; solute carrier family 11 (proton-coupled divalent metal ion transporters); solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 40 (iron-regulated transporter), member 1; solute carrier family 40 member 1

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Product Specific Notices

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.


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