HTRA2/Omi is the mammalian homolog of the bacterial high temperature requirement protein (HTRA). HTRA2/Omi is a homotrimeric serine protease that localizes to the mitochondria and is processed to expose an N-terminal reaper-like motif similar to SMAC/Diablo. HTRA2/Omi is released from the mitochondria in response to apoptotic insult and can interact with the BIR2 or BIR3 domains of XIAP to relieve caspase-IAP inhibition.
Human HTRA2/Omi (NP_037379.1) VersaClone cDNA
R&D Systems | Catalog # RDC3036
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Background: HTRA2/Omi
Long Name
High Temperature Requirement Protein-2
Alternate Names
Omi, PRSS25
Gene Symbol
HTRA2
UniProt
Additional HTRA2/Omi Products
Product Documents for Human HTRA2/Omi (NP_037379.1) VersaClone cDNA
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Product Specific Notices for Human HTRA2/Omi (NP_037379.1) VersaClone cDNA
For research use only
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Associated Pathways
