Human Kirrel1/NEPH1 (NP_060710) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Human Kirrel1/NEPH1 (NP_060710) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: Kirrel1/NEPH1

Kirrel (kin of irregular chiasm-1-like) proteins, also known as the NEPH (nephrin-like) family, are type I transmembrane glycoproteins within the immunoglobulin superfamily. Kirrel1 (NEPH1), Kirrel2 (NEPH3, Filtrin, NLG-1) and Kirrel3 (NEPH2, kirre) share 34 - 44% amino acid (aa) identity, and all interact with nephrin, podocin and the adaptor molecule ZO-1 (1, 4). All can be found in podocytes of the kidney glomerulus, and play a role in barrier function in the slit diaphragm. (2-6). Kirrel1 can also be found in central nervous system neurons, pancreas and placenta, Kirrel2 in pancreatic islet beta cells, brain and lymph nodes, and Kirrel3 in the brain and bone marrow, typically at sites where nephrin is also expressed.

Long Name
Kin of Irregular Chiasm-like 1
Entrez Gene IDs
55243 (Human); 170643 (Mouse); 310695 (Rat)
Alternate Names
FLJ10845; kin of IRRE like (Drosophila); KIRREL; Kirrel1; MGC129542; MGC129543; NEPH1; nephrin-like protein 1


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