Human Latent TGF‑ beta  bp2/LTBP‑2 Alexa Fluor™ Plus 680‑conjugated Antibody

R&D Systems | Catalog # FAB3850AFP680

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 327318
View all Latent TGF-beta bp2/LTBP-2 Primary Antibodies »

Product Specifications

Specificity

Detects human Latent TGF‑ beta bp2/LTBP‑2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse LTMP-4 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Latent TGF-beta bp2/LTBP-2

LTBP-2 is a 240 kDa member of the LTBP and fibrillin families. Unlike other LTBP, LTBP-2 is not a component of the large latent TGF-beta complex. LTBP-2 is a secreted calcium-binding extracellular matrix glycoprotein of elastic tissue 10 nm microfibrils, especially in the lung. The 1786 aa mature human LTBP2 contains 20 EGF‑like domains and four 8-cysteine repeats and shares 80% aa identity with mouse LTBP-2. An RGD sequence and a proline-rich sequence may mediate adhesion of melanoma cells, but for fibroblasts LTBP-2 may actually be an antiadhesion protein. In vivo, proteolysis by plasmin and elastase is likely and may cleave putative adhesion sites.

Alternate Names

Latent TGFbeta bp2, LTBP-2, LTBP2

Entrez Gene IDs

4053 (Human)

Gene Symbol

LTBP2

UniProt

NP_000419

Additional Latent TGF-beta bp2/LTBP-2 Products

Product Documents

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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