Human Neuroligin 2/NLGN2 (NP_065846.1) VersaClone cDNA

Catalog # Availability Size / Price Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

R&D Systems VersaClone cDNA Plasmids
1 Image
Product Details

Human Neuroligin 2/NLGN2 (NP_065846.1) VersaClone cDNA Summary


Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Product Datasheets

You must select a language.


Background: Neuroligin 2/NLGN2

Neuroligin 2 (NLGN2) is one of several type I transmembrane Neuroligins that are expressed on neuronal postsynaptic densities. Neuroligins play an important role in synaptic development and function. Mature human Neuroligin 2 is a 105 kDa protein that consists of a 663 amino acid (aa) extracellular domain (ECD) with a catalytically inactive cholinesterase-like domain, a 21 aa transmembrane segment, and a 137 aa cytoplasmic tail. Within the ECD, human Neuroligin 2 shares 98% aa sequence identity with mouse and rat Neuroligin 2. Alternate splicing generates an isoform with a 17 aa insertion at splice site A within the ECD. This recombinant protein does not contain the splice site A insert (-SS A). Neuroligin 2 is expressed on neurons in the brain and also on pancreatic beta cells where it facilitates insulin secretion. The -SS A isoform is uniformly expressed among inhibitory and excitatory synapses, while the +SS A isoform is enriched at inhibitory GABAergic synapses. Neuroligin 2 clusters at postsynaptic densities in association with other postsynaptic proteins including S-SCAM, PSD-95, gephyrin, and Neuroligin 3. Synaptic maturation is promoted by the binding of Neuroligin 2 with presynaptic Neurexins, and these interactions are restricted to particular combinations of isoforms of the binding partners. Neuroligin 2 interacts with the alpha and beta forms of Neurexin 1, 2, and 3. Its -SS A and +SS A isoforms are bound equally well by Neurexin 1 beta isoforms (-SS4 or +SS4), although only the Neurexin 1 beta +SS4 isoform can induce development of Neuroligin 2-dependent GABAergic contacts.

Entrez Gene IDs
57555 (Human); 216856 (Mouse); 117096 (Rat)
Alternate Names
EC 3.1.1; EC; KIAA1366neuroligin-2; Neuroligin 2; NLGN2


No product specific FAQs exist for this product, however you may

View all cDNA Clone FAQs

Reviews for Human Neuroligin 2/NLGN2 (NP_065846.1) VersaClone cDNA

There are currently no reviews for this product. Be the first to review Human Neuroligin 2/NLGN2 (NP_065846.1) VersaClone cDNA and earn rewards!

Have you used Human Neuroligin 2/NLGN2 (NP_065846.1) VersaClone cDNA?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review