Human NK1R APC-conjugated Antibody

Catalog # Availability Size / Price Qty
Detection of NK1R in THP‑1 Human Cell Line by Flow Cytometry.
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Product Details
Citations (1)
Supplemental Products

Human NK1R APC-conjugated Antibody Summary

Species Reactivity
Detects human NK1R in ELISAs.
Monoclonal Mouse IgG3 Clone # 694501
Protein A or G purified from hybridoma culture supernatant
HEK293 human embryonic kidney cell line transfected with human NK1R
Accession # P25103
Supplied in a saline solution containing BSA and Sodium Azide.
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)


Recommended Concentration
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of NK1R antibody in THP‑1 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of NK1R in THP‑1 Human Cell Line by Flow Cytometry. THP-1 human acute monocytic leukemia cell line was stained with Mouse Anti-Human NK1R APC-conjugated Monoclonal Antibody (Catalog # FAB66871A, filled histogram) or isotype control antibody (Catalog # IC007A, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: NK1R

NK1R (Neurokinin-1 Receptor), gene name TACR1 (Tachykinin Receptor-1), is an ~80 kDa 7-transmembrane glycoprotein receptor for the proinflammatory tachykinin neuropeptide, Substance P. NK1R is constitutively or inducibly expressed on a wide variety of cells, including monocytes, macrophages, microglia, lymphocytes, neutrophils, mast cells, and neurons. The 407 amino acid (aa) human NK1R contains 89 extracellular aa over multiple segments which collectively share 92% aa identity with corresponding regions of mouse and rat NK1R. An ~50 kDa short isoform that ends at aa 311 lacks almost all of the C-terminal cytoplasmic signaling region. It is the only form expressed in human monocytes and undifferentiated THP-1 cells, and its function appears to differ from the long isoform.

Long Name
Neurokinin-1 Receptor
Entrez Gene IDs
6869 (Human); 21336 (Mouse); 24807 (Rat)
Alternate Names
NK1R; NK-1R; NK1Rneurokinin 1 receptor; NKIR; SPR; SPRsubstance-P receptor; TAC1R; TAC1Rtachykinin 1 receptor (substance P receptor, neurokinin 1 receptor); tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor); tachykinin receptor 1NK-1 receptor; TACR1

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Citation for Human NK1R APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors
    Authors: A Taracanova, M Alevizos, A Karagkouni, Z Weng, E Norwitz, P Conti, SE Leeman, TC Theoharide
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry


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