Human Siglec-12 (NP_443729) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC1655
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Human Siglec-12 (NP_443729) VersaClone cDNA Summary

Product Datasheets

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Siglec-12

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

Long Name
Sialic Acid Binding Ig-like Lectin 12
Entrez Gene IDs
89858 (Human); 83382 (Mouse)
Alternate Names
FLJ38600; S2V; sialic acid binding Ig-like lectin 12; sialic acid-binding Ig-like lectin 12; Siglec-12; SIGLECL1; SIGLECL1Sialic acid-binding Ig-like lectin-like 1; SIGLEC-like 1; Siglec-XII; SLG; SLGSiglec-L1

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