Human XPA Alexa Fluor® 532-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: XPA

The Xeroderma Pigmentosum A (XPA) protein is a component of a large complex that binds to damaged DNA to facilitate nucleotide excision repair (NER). XPA binds in a complex with Replication Protein A (RPA), XPG, and TFIIH (a subcomplex of the RNA polymerase II transcription initiation complex). XPA is thought to stabilize the binding of RPA to DNA, and thus aid in specific recognition of the damaged base. Because of their NER defect, XP patients exhibit hypersensitivity to ultraviolet light and have a heightened incidence of skin cancer.

Product Datasheets

Related Research Areas

• DNA Damage and Repair
• DNA Modifying Enzymes
• Nucleotide Excision Repair/Transcription Coupled Repair