IEM 1925 dihydrobromide

Catalog # Availability Size / Price Qty
4198/10
4198/50
IEM 1925 dihydrobromide | CAS No. 258282-23-4 | AMPA Receptor Antagonists
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Description: Voltage- and use-dependent open-channel AMPA blocker

Chemical Name: N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide

Purity: ≥98%

Product Details
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Biological Activity

Voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking receptors more potently than GluA2-containing receptors (KD for GluA2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 (Cat. No. 4199) due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.

Technical Data

M.Wt:
422.24
Formula:
C17H28N2.2HBr
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
258282-23-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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