Catalog Number: 4198
Chemical Name: N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide
Biological Activity
Voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking receptors more potently than GluR2-containing receptors (KD for GluR2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 (Cat. No. 4199) due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.
Technical Data
  • M.Wt:
    422.24
  • Formula:
    C17H28N2.2HBr
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    258282-23-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Voltage-dependent block of native AMPA receptor channels by dicationic compounds.
    Tikhonov et al.
    Br.J.Pharmacol., 2000;129:265
  2. Inhibition of spinal Ca2+-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects.
    Kopach et al.
    Front.Cell Neurosci., 2016;10

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