INCA-6

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2162/10
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INCA-6 | CAS No. 3519-82-2 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Inhibitor of calcineurin-substrate association

Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

Technical Data

M.Wt:
284.31
Formula:
C20H12O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
3519-82-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
    Roehrl et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:7554

Product Datasheets

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Citations for INCA-6

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3 Citations: Showing 1 - 3

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