Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd
= 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
Soluble to 20 mM in DMSO
Store at RT
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Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
Roehrl et al.
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