Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
Biological ActivityInhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
Roehrl et al.
Citations for INCA-6
The citations listed below are publications that use Tocris products. Selected citations for INCA-6 include:
3 Citations: Showing 1 - 3
NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.
Authors: Bretz Et al.
Exp Eye Res 2015;5:14963
NFATc1 activity regulates the expression of myocilin induced by dexameth.
Authors: Faralli Et al.
Nat Chem Biol 2015;130:42614
RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα.
Authors: Savage Et al.
PLoS One 2015;10:e0116941
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for INCA-6
There are currently no reviews for this product. Be the first to review INCA-6 and earn rewards!
Have you used INCA-6?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image