Catalog Number: 2162
Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
Biological Activity
Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
Technical Data
  • M.Wt:
    284.31
  • Formula:
    C20H12O2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    3519-82-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
    Roehrl et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:7554
Citations:

The citations listed below are publications that use Tocris products. Selected citations for INCA-6 include:

3 Citations: Showing 1 - 3
Filter your results:

  1. NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.
    Authors: Bretz Et al.
    Exp Eye Res 2015;5:14963
  2. NFATc1 activity regulates the expression of myocilin induced by dexamethasone.
    Authors: Faralli Et al.
    Nat Chem Biol 2015;130:42614
  3. RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα.
    Authors: Savage Et al.
    PLoS One 2015;10:e0116941

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