Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
Biological ActivityINCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
Roehrl et al.
Citations for INCA-6
The citations listed below are publications that use Tocris products. Selected citations for INCA-6 include:
3 Citations: Showing 1 - 3
NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.
Authors: Bretz Et al.
Exp Eye Res 2015;5:14963
NFATc1 activity regulates the expression of myocilin induced by dexameth.
Authors: Faralli Et al.
Nat Chem Biol 2015;130:42614
RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα.
Authors: Savage Et al.
PLoS One 2015;10:e0116941
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