Indirubin-3'-oxime

Catalog # Availability Size / Price Qty
1813/10
1813/50
Indirubin-3'-oxime | CAS No. 160807-49-8 | GSK-3 Inhibitors
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Description: GSK-3β inhibitor; also inhibits cdks and other protein kinases
Alternative Names: Indirubin-3'-monoxime

Chemical Name: 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Purity: ≥99%

Product Details
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Biological Activity

Inhibitor of GSK-3β (IC50 = 190 nM) and cyclin dependent kinases (cdks; IC50 values are 0.05, 0.18 and 0.25-0.5 βM for cdk9, cdk1 and cdk2, respectively). Also reported to inhibit AMPK, LCK and SGK. Inhibits cdk5- and GSK-3β-mediated tau phosphorylation. Induces cell cycle arrest and inhibits cell proliferation.

Technical Data

M.Wt:
277.28
Formula:
C16H11N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
160807-49-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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