Chemical Name: 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Biological ActivityIndirubin-3'-oxime is a inhibitor of GSK-3β (IC50 = 190 nM) and cyclin dependent kinases (cdks; IC50 values are 0.05, 0.18 and 0.25-0.5 βM for cdk9, cdk1 and cdk2, respectively). Also reported to inhibit AMPK, LCK and SGK. Inhibits cdk5- and GSK-3β-mediated tau phosphorylation. Induces cell cycle arrest and inhibits cell proliferation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The specificities of protein kinase inhibitors: an update.
Bain et al.
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
Hoessel et al.
Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease.
Leclerc et al.
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