Protein kinase inhibitor; inhibits cyclin-dependent kinases (IC50
= 0.18 - 3.33 μ
M) and GSK-3β
= 0.19 μ
M). Inhibits CDK5- and GSK-3β
-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The specificities of protein kinase inhibitors: an update.
Bain et al.
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
Hoessel et al.
Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease.
Leclerc et al.