Catalog Number: 5147
Alternate Names: KW-6002
Chemical Name: 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
Biological Activity
Potent and selective adenosine A2A receptor antagonist (Ki values are 2.2 and 150 nM for A2A and A1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.
    Kanda et al.
    Neuroreport, 1998;9:2857
  2. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.
    Shiozaki et al.
    Psychopharmacology, 1999;147:90
  3. Adenosine A2A antagonists with potent anti-cataleptic activity.
    Shimada et al.
    Bioorg.Med.Chem.Lett., 1997;7:2349

The citations listed below are publications that use Tocris products. Selected citations for Istradefylline include:

1 Citations: Showing 1 - 1

  1. On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
    Authors: Wydra Et al.
    PLoS One 2015;232:1767

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