Catalog # Availability Size / Price Qty
Istradefylline | CAS No. 155270-99-8 | Adenosine A2a Receptor Antagonists
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Description: Potent and selective A2A antagonist
Alternative Names: KW-6002

Chemical Name: 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione

Purity: ≥99%

Product Details
Citations (3)
Supplemental Products

Biological Activity

Istradefylline is a potent and selective adenosine A2A receptor antagonist (Ki values are 2.2 and 150 nM for A2A and A1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Adenosine A2A antagonists with potent anti-cataleptic activity.
    Shimada et al.
    Bioorg.Med.Chem.Lett., 1997;7:2349
  2. Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.
    Kanda et al.
    Neuroreport, 1998;9:2857
  3. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by rese. or MPTP.
    Shiozaki et al.
    Psychopharmacology, 1999;147:90

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Citations for Istradefylline

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