Catalog # Availability Size / Price Qty
Cat.No. 5147 - Istradefylline | C20H24N4O4 | CAS No. 155270-99-8
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Description: Potent and selective adenosine A2A receptor antagonist
Alternative Names: KW-6002

Chemical Name: 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products

Biological Activity

Potent and selective adenosine A2A receptor antagonist (Ki values are 2.2 and 150 nM for A2A and A1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.
    Kanda et al.
    Neuroreport, 1998;9:2857
  2. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.
    Shiozaki et al.
    Psychopharmacology, 1999;147:90
  3. Adenosine A2A antagonists with potent anti-cataleptic activity.
    Shimada et al.
    Bioorg.Med.Chem.Lett., 1997;7:2349

Product Datasheets

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Citation for Istradefylline

The citations listed below are publications that use Tocris products. Selected citations for Istradefylline include:

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