Istradefylline

Tocris Bioscience | Catalog # 5147

Potent and selective A2A antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective A2A antagonist

Alternative Names

KW-6002
View all Adenosine A2a Receptor Antagonists »

Product Description

Istradefylline is a potent and selective adenosine A2A receptor antagonist (Ki values are 2.2 and 150 nM for A2A and A1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.

Product Specifications for Istradefylline

Molecular Weight

384.43

Formula

C20H24N4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione

CAS Number

155270-99-8

PubChem ID

5311037

InChI Key

IQVRBWUUXZMOPW-PKNBQFBNSA-N

SMILES

O=C1N(CC)C(C(N(C)C(/C=C/C3=CC(OC)=C(OC)C=C3)=N2)=C2N1CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.69 20

Preparing Stock Solutions for Istradefylline

The following data is based on the product molecular weight 384.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.01 mL 65.03 mL 130.06 mL
1 mM 2.60 mL 13.01 mL 26.01 mL
2 mM 1.30 mL 6.50 mL 13.01 mL
10 mM 0.26 mL 1.30 mL 2.60 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for Istradefylline

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Istradefylline

For research use only

Customer Reviews for Istradefylline (1)

4 out of 5
1 Customer Rating
5 Stars
0%
4 Stars
100%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Istradefylline?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card
Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Istradefylline on D2R antagonist induced motor impairment
    Name: Yunmin Ding
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 12/07/2018
    Istradefylline from Tocris worked wonderfully. At 3 mg/kg (in suspension in 8% Tween 80 in 0.9% saline), it reversed motor impairment induced by 0.16 mg/kg of the D2R antagonist eticlopride
    i.p.

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All