Chemical Name: 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
Biological ActivityIstradefylline is a potent and selective adenosine A2A receptor antagonist (Ki values are 2.2 and 150 nM for A2A and A1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Adenosine A2A antagonists with potent anti-cataleptic activity.
Shimada et al.
Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.
Kanda et al.
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by rese. or MPTP.
Shiozaki et al.
Citations for Istradefylline
The citations listed below are publications that use Tocris products. Selected citations for Istradefylline include:
3 Citations: Showing 1 - 3
Istradefylline reduces memory deficits in aging mice with amyloid pathology.
Authors: Orr Et al.
Neurobiol Dis 2018;110:29
Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
Authors: Cheng Et al.
On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
Authors: Wydra Et al.
PLoS One 2015;232:1767
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