Chemical Name: 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
Biological ActivityPotent and selective adenosine A2A receptor antagonist (Ki values are 2.2 and 150 nM for A2A and A1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.
Kanda et al.
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.
Shiozaki et al.
Adenosine A2A antagonists with potent anti-cataleptic activity.
Shimada et al.
Citation for Istradefylline
The citations listed below are publications that use Tocris products. Selected citations for Istradefylline include:
1 Citation: Showing 1 - 1
On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
Authors: Wydra Et al.
PLoS One 2015;232:1767
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