Chemical Name: 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
Biological ActivityItraconazole is a SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
Kim et al.
Cancer Cell, 2010;17:388
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.
Kim et al.
Cancer Cell, 2013;23:23
Inhibition of angiogenesis by the antifungal drug itracon.
Chong et al.
ACS Chem.Biol., 2007;2:263
Repurposing the clinically efficacious antifungal agent itracon. as an anticancer chemotherapeutic.
Pace et al.
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