Itraconazole

  
Catalog Number:5981
Chemical Name:4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
Product Details
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Biological Activity
SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.
Technical Data
  • M.Wt:
    705.63
  • Formula:
    C35H38Cl2N8O4
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    84625-61-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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