Itraconazole

Tocris Bioscience | Catalog # 5981

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)
Tocris Bioscience

Key Product Details

Description

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)
View all Smoothened Receptor Antagonists »

Product Description

Itraconazole is a SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.

Product Specifications for Itraconazole

Molecular Weight

705.63

Formula

C35H38Cl2N8O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

CAS Number

84625-61-6

PubChem ID

3793

InChI Key

OPJPKRNKYPEBBY-YFWMVZQVSA-N

SMILES

CCC(N1N=CN(C2=CC=C(N3CCN(C4=CC=C(C=C4)OC[C@H]5CO[C@@](O5)(C6=C(C=C(C=C6)Cl)Cl)CN7C=NC=N7)CC3)C=C2)C1=O)C.CCC(N8N=CN(C9=CC=C(N%10CCN(C%11=CC=C(C=C%11)OC[C@@H]%12CO[C@](O%12)(C%13=C(C=C(C=C%13)Cl)Cl)CN%14C=NC=N%14)CC%10)C=C9)C8=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.11 20 with gentle warming

Preparing Stock Solutions for Itraconazole

The following data is based on the product molecular weight 705.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 7.09 mL 35.43 mL 70.86 mL
1 mM 1.42 mL 7.09 mL 14.17 mL
2 mM 0.71 mL 3.54 mL 7.09 mL
10 mM 0.14 mL 0.71 mL 1.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for Itraconazole

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Itraconazole

For research use only

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