Cyclopamine

Catalog # Availability Size / Price Qty
1623/1
Cyclopamine | CAS No. 4449-51-8 | Hedgehog Signaling Inhibitors
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Description: Inhibitor of Hedgehog (Hh) signaling

Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol

Purity: ≥97%

Product Details
Citations (8)
Reviews (1)

Biological Activity

Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo. Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Technical Data

M.Wt:
411.63
Formula:
C27H41NO2
Solubility:
Soluble to 5 mM in ethanol
Purity:
≥97%
Storage:
Desiccate at -20°C
CAS No:
4449-51-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Modulators of Hh signalling and stress fibres
By Anonymous on 11/09/2019
Application: Species: Human

Modulators of Hh signalling and stress fibres. Cyclopamine (Tocris Bioscience, 1623) was dissolved in ethanol and DMSO. The final concentration used for cells was 5 mM of cyclopamine.

PMID: 26996322

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