Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo
. Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.
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All Tocris products are intended for laboratory research use only.
Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened.
Chen et al.
Genes Dev., 2002;16:2743
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.
Bar et al.
Stem Cells, 2007;25:2524
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells.
D'Amour et al.
Cancer: a twist in a hedgehog's tale.
The citations listed below are publications that use Tocris products. Selected citations for Cyclopamine include:
Showing Results 1 - 5 of 5