JP 1302 dihydrochloride

Tocris Bioscience | Catalog # 2666

Potent and selective α2C antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective α2C antagonist
View all Adrenergic alpha-2 Receptor Antagonists »

Product Description

JP 1302 dihydrochloride is an α2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2-adrenoceptor subtypes (Ki values are 28, 1470, 1700 and 3150 nM for human α2C, α2B, α2D and α2A subtypes respectively). Potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro (KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.

Product Specifications for JP 1302 dihydrochloride

Molecular Weight

441.40

Formula

C24H24N4.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride

CAS Number

1259314-65-2

PubChem ID

49855035

InChI Key

VVZOADYFJAJZGL-UHFFFAOYSA-N

SMILES

CN(CC5)CCN5C(C=C4)=CC=C4NC2=C3C(C=CC=C3)=NC1=CC=CC=C12.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.14 100

Preparing Stock Solutions for JP 1302 dihydrochloride

The following data is based on the product molecular weight 441.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.33 mL 22.66 mL
5 mM 0.45 mL 2.27 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for JP 1302 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JP 1302 dihydrochloride

For research use only

Citations for JP 1302 dihydrochloride

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