-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2
-adrenoceptor subtypes (Ki
values are 28, 1470, 1700 and 3150 nM for human α2C
subtypes respectively). Potently antagonizes adrenalin-stimulated 35
S binding in vitro
= 16 nM) and produces antidepressant and antipsychotic-like effects in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
JP-1302: a new tool to shed light on the roles of α2C-adrenoceptors in brain.
Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302.
Sallinen et al.
The citations listed below are publications that use Tocris products. Selected citations for JP 1302 dihydrochloride include:
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