JP 1302 dihydrochloride

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JP 1302 dihydrochloride | CAS No. 1259314-65-2 | Adrenergic alpha-2 Receptor Antagonists
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Description: Potent and selective α2C antagonist

Chemical Name: N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

α2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2-adrenoceptor subtypes (Ki values are 28, 1470, 1700 and 3150 nM for human α2C, α2B, α2D and α2A subtypes respectively). Potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro (KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.

Technical Data

M.Wt:
441.4
Formula:
C24H24N4.2HCl
Solubility:
Soluble to 100 mM in water and to 5 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at -20°C
CAS No:
1259314-65-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for JP 1302 dihydrochloride

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