Catalog Number: 2514
Chemical Name: N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide
Biological Activity
EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively). Suppresses PGE2-induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
    Oliva et al.
    Eur.J.Pharmacol., 2006;530:40
  2. Lipopolysaccharide induces epithelium- and prostaglandin E2-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2.
    Balzary et al.
    J.Pharmacol.Exp.Ther., 2006;317:806
  3. Prostaglandin receptor EP4 mediates the bone anabolic effects of PGE2.
    Machwate et al.
    Mol.Pharmacol., 2001;60:36

The citations listed below are publications that use Tocris products. Selected citations for L-161,982 include:

Showing Results 1 - 1 of 1

  1. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
    Authors: Chia Et al.
    BMC Pharmacol
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