receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki
values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μ
M for human EP4
, TP, EP3
, DP, FP, IP, EP1
receptors respectively). Suppresses PGE2
-induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
Oliva et al.
Lipopolysaccharide induces epithelium- and prostaglandin E2-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2.
Balzary et al.
Prostaglandin receptor EP4 mediates the bone anabolic effects of PGE2.
Machwate et al.
The citations listed below are publications that use Tocris products. Selected citations for L-161,982 include:
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