Chemical Name: N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide
Biological ActivityL-161,982 is an EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively). Suppresses PGE2-induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Prostaglandin receptor EP4 mediates the bone anabolic effects of PGE2.
Machwate et al.
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
Oliva et al.
Lipopolysaccharide induces epithelium- and prostaglandin E2-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2.
Balzary et al.
Citations for L-161,982
The citations listed below are publications that use Tocris products. Selected citations for L-161,982 include:
3 Citations: Showing 1 - 3
Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.
Authors: Guillem-Llobat Et al.
Lubiprostone reverses the inhibitory action of mor. on mucosal secretion in human small intestine.
Authors: Sun Et al.
Dig Dis Sci 2011;56:330
Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
Authors: Chia Et al.
BMC Pharmacol 2011;11:10
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in vivo survival assay