L-371,257

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2410/10
L-371,257 | CAS No. 162042-44-6 | Oxytocin Receptor Antagonists
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Description: Potent and selective oxytocin receptor antagonist

Chemical Name: 1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

Potent, high affinity human oxytocin (OT) receptor antagonist (Ki = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V1a and V2. Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Decreases length of U-87MG cell projections induced by retinoic acid (Cat.No.0695). Orally active.

Technical Data

M.Wt:
507.59
Formula:
C28H33N3O6
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
162042-44-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for L-371,257

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