Catalog Number: 0695
Alternate Names: Tretinoin, ATRA
Chemical Name: 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid
Biological Activity
Endogenous agonist for retinoic acid receptors (IC50 = 14 nM for RARα, RARβ and RARγ receptors). Also promotes differentiation of mouse embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro. Proposed ligand of RORβ (Kd = 280 nM). Activates autophagy.
Technical Data
  • M.Wt:
    300.44
  • Formula:
    C20H28O2
  • Solubility:
    Soluble to 25 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    302-79-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. All-trans retinoic acid is a ligand for the orphan nuclear receptor RORβ.
    Stehlin-Gaon et al.
    Nat.Struct.Biol., 2003;10:820
  3. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.
    Apfel et al.
    Proc.Natl.Acad.Sci.U.S.A., 1992;89:7129
  4. Differentiation of embryonic stem cells into adipocytes in vitro.
    Dani et al.
    J. Cell Sci., 1997;110:1279
  5. Characterisation of human cellular retinoic acid binding proteins-1 and -2: ligand binding affinities and distribution in skin.
    Sanquer and Gilchrest
    Arch.Biochem.Biophys., 1994;311:86
  6. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Retinoic acid include:

4 Citations: Showing 1 - 4
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  1. Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
    Authors: Bohnenpoll
    Sci Rep 2017;7(1):14803
  2. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
    Authors: Lewis Et al.
    J Med Food 2015;11:189
  3. Evolution and functional characterisation of melanopsins in a deep-sea chimaera (elephant shark, Callorhinchus milii).
    Authors: Davies Et al.
    PLoS One 2012;7:e51276
  4. Berberine promotes axonal regeneration in injured nerves of the peripheral nervous system.
    Authors: Han Et al.
    Physiol Behav 2012;15:413

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