Retinoic acid

  ( 4 citations )    
Product Datasheet
Catalog Number:0695
Alternate Names:Tretinoin, ATRA
Chemical Name:3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid
Product Details
Citations (4)
Reviews
Biological Activity
Endogenous agonist for retinoic acid receptors (IC50 = 14 nM for RARα, RARβ and RARγ receptors). Also promotes differentiation of mouse embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro. Proposed ligand of RORβ (Kd = 280 nM). Activates autophagy.
Technical Data
  • M.Wt:
    300.44
  • Formula:
    C20H28O2
  • Solubility:
    Soluble to 25 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    302-79-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Retinoic acid include:

4 Citations: Showing 1 - 4
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  1. Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
    Authors: Bohnenpoll
    Sci Rep  2017;7(1):14803
  2. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
    Authors: Lewis Et al.
    J Med Food  2015;11:189
  3. Evolution and functional characterisation of melanopsins in a deep-sea chimaera (elephant shark, Callorhinchus milii).
    Authors: Davies Et al.
    PLoS One  2012;7:e51276
  4. Berberine promotes axonal regeneration in injured nerves of the peripheral nervous system.
    Authors: Han Et al.
    Physiol Behav  2012;15:413

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