Endogenous agonist for retinoic acid receptors (IC50
= 14 nM for RARα
receptors). Also promotes differentiation of mouse embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro
. Proposed ligand of RORβ
= 280 nM).
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All Tocris products are intended for laboratory research use only.
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
All-trans retinoic acid is a ligand for the orphan nuclear receptor RORβ.
Stehlin-Gaon et al.
A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.
Apfel et al.
Differentiation of embryonic stem cells into adipocytes in vitro.
Dani et al.
J. Cell Sci., 1997;110:1279
Characterisation of human cellular retinoic acid binding proteins-1 and -2: ligand binding affinities and distribution in skin.
Sanquer and Gilchrest
The citations listed below are publications that use Tocris products. Selected citations for Retinoic acid include:
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