Chemical Name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
Biological ActivityL-trans-2,4-PDC is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer.
Bridges et al.
Regional differences in the inhibition of L-glutamate amd L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylic threo-3-hydroxy-D-aspartate and D-aspartate.
Mitrovic and Johnston
Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus.
Zuiderwijk et al.
Citations for L-trans-2,4-PDC
The citations listed below are publications that use Tocris products. Selected citations for L-trans-2,4-PDC include:
4 Citations: Showing 1 - 4
K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
Authors: Heinrich Et al.
Br J Pharmacol 2012;167:1003
Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures.
Authors: Yin and Weiss
Brain Res 2012;1448:153
Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes.
Authors: Beaulé Et al.
PLoS One 2009;4:e7476
Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.
Authors: Young Et al.
PLoS One 2007;26:78
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