Catalog Number: 0298
Alternate Names: trans-4-Carboxy-L-proline
Chemical Name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
Biological Activity
Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.
Technical Data
  • M.Wt:
    159.14
  • Formula:
    C6H9NO4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    64769-66-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer.
    Bridges et al.
    J.Med.Chem., 1991;34:717
  2. Regional differences in the inhibition of L-glutamate amd L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylic threo-3-hydroxy-D-aspartate and D-aspartate.
    Mitrovic and Johnston
    Neurochem.Int., 1994;24:583
  3. Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus.
    Zuiderwijk et al.
    Eur.J.Pharmacol., 1996;307:275
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-trans-2,4-PDC include:

4 Citations: Showing 1 - 4
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  1. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
    Authors: Heinrich Et al.
    Br J Pharmacol 2012;167:1003
  2. Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures.
    Authors: Yin and Weiss
    Brain Res 2012;1448:153
  3. Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes.
    Authors: Beaulé Et al.
    PLoS One 2009;4:e7476
  4. Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.
    Authors: Young Et al.
    PLoS One 2007;26:78
Tocris Small Molecules
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