Legumain/Asparaginyl Endopeptidase Antibody (S06-7G1)

Novus Biologicals | Catalog # NBP3-19561

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S06-7G1 expressed in HEK293
View all Legumain/Asparaginyl Endopeptidase Primary Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Legumain/Asparaginyl Endopeptidase (Uniprot # Q99538)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Legumain/Asparaginyl Endopeptidase Antibody (S06-7G1)

Legumain/Asparaginyl Endopeptidase Antibody (S06-7G1)

Western Blot: Legumain/Asparaginyl Endopeptidase Antibody (S06-7G1) [NBP3-19561] -

Western Blot: Legumain/Asparaginyl Endopeptidase Antibody (S06-7G1) [NBP3-19561] - Western blot detection of Jurkat, Hela cell lysates using NBP3-19561. Predicted band size: 49kDa. Observed band size: 56, 46, 37kDa.

Applications for Legumain/Asparaginyl Endopeptidase Antibody (S06-7G1)

Application
Recommended Usage

Western Blot

1:1000-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

10mM PBS (pH 7.4), 150mM sodium chloride, 0.05% BSA, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Legumain/Asparaginyl Endopeptidase

Legumain encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq]

Alternate Names

AEP, Asparaginyl Endopeptidase, LGMN

Gene Symbol

LGMN

Additional Legumain/Asparaginyl Endopeptidase Products

Product Documents for Legumain/Asparaginyl Endopeptidase Antibody (S06-7G1)

Certificate of Analysis

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Product Specific Notices for Legumain/Asparaginyl Endopeptidase Antibody (S06-7G1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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