Letrozole

Key Product Details

Product Description

Letrozole is a potent, reversible non-steroidal aromatase inhibitor (IC₅₀ = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.

Product Specifications for Letrozole

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Letrozole

The following data is based on the product molecular weight 285.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.51 mL	17.53 mL	35.05 mL
5 mM	0.70 mL	3.51 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.51 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Bhatnagar Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 1990 PMID: 2149502
• Bhatnagar The discovery and mechanism of action of letr. Breast Cancer Res.Treat. 2007 PMID: 17912633
• Mitropoulou Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int.J.Cancer 2003 PMID: 12569569

Product Documents for Letrozole