Potent, reversible non-steroidal aromatase inhibitor (IC50
= 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells.
Mitropoulou et al.
Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.
Bhatnagar et al.
J.Steroid Biochem.Mol.Biol., 1990;37:1021
The discovery and mechanism of action of letrozole.
Breast Cancer Res.Treat., 2007;105:7
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