Chemical Name: 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Biological ActivityPotent, reversible non-steroidal aromatase inhibitor (IC50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells.
Mitropoulou et al.
Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.
Bhatnagar et al.
J.Steroid Biochem.Mol.Biol., 1990;37:1021
The discovery and mechanism of action of letrozole.
Breast Cancer Res.Treat., 2007;105:7
Citations for Letrozole
The citations listed below are publications that use Tocris products. Selected citations for Letrozole include:
2 Citations: Showing 1 - 2
Oestradiol synthesized by female neurons generates sex differences in neuritogenesis.
Authors: Ruiz-Palmero Et al.
Scientific Reports 2016;6:31891
Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
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