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Leuprolide

2873 Datasheet / COA / SDS

Discontinued Product

2873 has been discontinued.
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Leuprolide
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Description: GnRH receptor agonist
Alternative Names: Leuoprorelin
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Biological Activity

Leuprolide is a gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, LHRH) receptor agonist. Suppresses estradiol, LH and FSH serum levels and represses the growth of experimental rat endometriosis.

Technical Data

M.Wt:
1209.41
Formula:
C59H84N16O12
Sequence:
XHWSYLLRP

(Modifications: X1 = Glp, Pro-9 = Pro-NHEt)

Solubility:
Soluble to 0.50 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
53714-56-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats.
    Okada et al.
    J.Pharmacol.Exp.Ther., 1988;244:744
  2. LHRH antagonist attenuates the effect of fluox. on marble-burying behavior in mice.
    Uday et al.
    Eur.J.Pharmacol., 2007;563:155
  3. Effects of the luteinising hormone-releasing hormone (LH-RH) agonist leupr. on adenylyl cyclase regulation through G-protein coupled receptors in rat ventral prostate.
    Salvador et al.
    Eur.J.Pharmacol., 2001;37:641

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