Catalog Number: 2873
Alternate Names: Leuoprorelin
Biological Activity
Gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, LHRH) receptor agonist. Suppresses estradiol, LH and FSH serum levels and represses the growth of experimental rat endometriosis.
Technical Data
  • M.Wt:
    1209.41
  • Formula:
    C59H84N16O12
  • Sequence:
    XHWSYLLRP

    (Modifications: X1 = Glp, Pro-9 = Pro-NHEt)

  • Solubility:
    Soluble to 0.50 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    53714-56-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats.
    Okada et al.
    J.Pharmacol.Exp.Ther., 1988;244:744
  2. LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice.
    Uday et al.
    Eur.J.Pharmacol., 2007;563:155
  3. Effects of the luteinising hormone-releasing hormone (LH-RH) agonist leuprolide on adenylyl cyclase regulation through G-protein coupled receptors in rat ventral prostate.
    Salvador et al.
    Eur.J.Pharmacol., 2001;37:641

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